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目的：探讨乳头瘤病毒定性检测( HPV- DNA)与液基薄层细胞学检查技术( TCT)在宫颈癌前病变中的诊断价值。方法：分别采用HPV- DNA 及TCT 法检测1536 例患者，对TCT 阳性、HPV- DNA 阳性病例者进行阴道镜下活检。结果：随着病理诊断级别的升高，高危型HPV 感染率上升，而低危型HPV 感染多见于轻度不典型增生( CINⅠ) 及其以下病变，HPV 混合感染在各组间未见明显趋势。HPV-DNA 检测与宫颈活检的符合率为66.78%。随着病理级别的升高，不典型鳞状细胞( ASCUS) 组的感染率呈降低趋势，鳞状上皮内低度病变( LSIL)组感染率亦呈下降趋势，而鳞状上皮内高度病变( HSIL)组和鳞癌（SCC）组感染率均呈上升趋势，TCT 检测与组织学诊断的符合率为66.67%，与HPV-DNA 检查比较，差异无统计学意义（X2=0.001，P>0.05）。结论：HPVDNA 、TCT 及宫颈活检三者检测相结合，能明显提高诊断的正确性。

英文摘要:

Objective: To study the clinical application value of the qualitative detection of human papillomavirus (HPV-DNA) and ThinPrep cytology technique (TCT) in prevention of cervical lesions and cervical cancer. Methods: Totally 1536 cases were screened by HPV-DNA test or TCT test．Directed biopsies under colposcopy were taken either in both positive test. Results: The pathological diagnosis level rose when high-risk HPV infection increased, while low-risk HPV infection was appeared more commonly in CIN I lesions, but HPV co-infection had no significant trend in each group. The compliance rate of HPV-DNA testing with the histological diagnosis was 66.78%. With the increased pathological grade, ASCUS group infection rate was decreasing, and LSIL group infection rate was also found a downward trend, while the prevalence of HSIL group and SCC group were rising. The compliance rate of TCT test with the histological diagnosis was 66.67 %, and there was no significantly difference between HPV-DNA test and TCT test (X2 = 0.001, P> 0.05).Conclusion:The combination ofHPV-DNA,TCTtest and cervical biopsycan significantlyimproved diagnostic accuracy.

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