| 姬振伟张涛马云雷李晓祥井文森蔡承魁孙海滨范清宇△.犬完整骨及骨水泥重建骨缺损微波灭活后的生物力学研究[J].现代生物医学进展英文版,2012,12(20):3827-3830. |
| 犬完整骨及骨水泥重建骨缺损微波灭活后的生物力学研究 |
| The Effect of Microwave Ablation on the Biomechanics of Intactand Reconstructed Canine Femur with Bone Cement |
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| DOI： |
| 中文关键词: 微波消融 原位灭活 生物力学 骨缺损 骨水泥 |
| 英文关键词: Microwave ablation Inactivation in situ Biomechanics Bone defect Bone cement |
| 基金项目: |
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| 中文摘要: |
| 目的：研究微波消融（microwave ablation）对结构正常及缺损后骨水泥修复重建的犬骨生物力学性能的影响。方法：取成年犬
股骨12 对，随机分为完整组和重建组，再随机选取每对股骨的一侧作为对照组，另一侧为实验组，试验由此分为四组：完整对照
组，完整微波组，重建对照组，重建微波组。然后将每根股骨制作成两个不同的骨标本，分别长3 cm 和6 cm。两种微波组的标本均
进行微波灭活，两种重建组的标本均制备成缺损模型并行骨水泥修复重建。然后分别对3、6 cm 两种标本行压缩和三点弯曲试
验。结果：完整对照组与完整微波组之间，重建对照组与重建微波组之间的最大压缩力、最大压缩位移、最大弯曲力及最大挠度等
均无显著性差异。结论：微波消融对结构正常的犬骨的生物力学性能无明显影响，且不会加剧对重建犬骨的力学强度的破坏。 |
| 英文摘要: |
| Objective: To investigate the effect of microwave ablation on the biomechanics of canine's bone specimens, both
structurally intact and reconstructed with bone cement in a defect model. Methods: 12 pairs (24 in all) of femurs were obtained from 12
adult dogs, which were randomly divided into two groups, structurally intact or reconstructed. Then, one femur of each pair was randomly
selected as the control and the other one for microwave treatment. In this way, four groups were formed: structurally intact control and
microwave group, reconstructed control and microwave group. Then, each femur was made into two kinds of bone specimens, 3 cm and
6 cm in length, respectively. Those specimens in the two microwave groups were devitalized by microwave ablation, and those in the two
reconstructed groups, after making a defect on them, were reconstructed with bone cement. Last, the specimens 3 cm in length were used
for compression test and the specimens 6 cm in length for three-point bending test. The maximum compression load and deflection and
the maximum bending load and flexibility of the bone specimens were measured, then the data were statistically analyzed. Results: There
was no significant statistical difference in maximum compression load, deflection, bending load and flexibility between the structurally
intact control and microwave group, neither was there significant statistical difference between the reconstructed control and microwave
group. Conclusions: Microwave ablation does not damage the biomechanical strength of the structurally intact bone specimens, neither
does it worsen the mechanical strength of the reconstructed bone specimen by bone cement. |
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