| 廖鑫王佳唐罗东何俊吴昌松梁敬心.幕上高血压脑出血小骨窗开颅术后C 反应蛋白及TNF-α 的变化及对转
归影响的临床分析[J].现代生物医学进展英文版,2012,12(19):3708-3710. |
| 幕上高血压脑出血小骨窗开颅术后C 反应蛋白及TNF-α 的变化及对转
归影响的临床分析 |
| The Variation of CRP and the TNF-α in the Vupratentorial HypertensiveCerebral Hemorrhage after Surgical Treated with Small Bone and theRelationship to the Patient's Condition and Prognostic |
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| DOI： |
| 中文关键词: 高血压脑出血 C 反应蛋白 TNF-α 临床分析 |
| 英文关键词: Hypertensive cerebral hemorrhage Tumor Necrosis Factor-alpha C-reactive protein Clinical analysis |
| 基金项目: |
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| 中文摘要: |
| 目的：探索幕上高血压脑出血术前及小骨窗开颅术后C 反应蛋白（CRP）及肿瘤坏死因子α（TNF-α）的变化与病情的关系及
对患者临床预后的预测价值。方法：38 例诊断为幕上高血压脑出血的患者，在明确手术指征后行小骨窗开颅术，于术前，术后第1
天，第7 天，第14 天监测患者的CRP 及TNF-α 的水平；并同时测定格拉斯哥昏迷评分（GSS）。另设30 例作为正常对照病例，一次
性抽取静脉血进行CRP 及TNF-α 进行检测。结果：①术前脑出血患者血中CRP 与TNF-α 的水平显著高于正常对照组；② 术
后CRP 与TNF-α 的水平仍继续上升，术后第7 天显著下降；③ CRP 及TNF-α 的水平与GCS 评分密切相关。结论：CRP 与
TNF-α 的水平可反映脑出血患者的病情，对病情转归有预测意义。 |
| 英文摘要: |
| Objective: To investigate the role and the rules of Tumor necrosis factor alpha and C-reactive protein of patients after
surgical treated with small bone with supratentorial hypertensive cerebral hemorrhage and relation with the GCS. Methods: 38 cases
diagnosed supratentorial hypertensive intracerebral hemorrhage were given surgery underwent craniotomy with small bone window after
a clear indication. The levels of CRP and TNF-αwere detected before and at 1 day, 7 days and 14 days after surgical treatment, and the
Glasgow coma score （GCS）also determination. We also have 30 cases as control of the CRP and TNF-α. Results: Preoperative serum
CRP and TNF-α levels were significantly higher than the control group. Postoperative CRP and TNF-α levels continued to rise，but
decreased after 7 days of surgical treatment. The levels of CRP and TNF-α are closely associated with the GCS score. Conclusions: CRP
and TNF-α levels may reflect patient's condition and prognostic with hypertensive intracerebral hemorrhage. |
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