| 周华1 杨春1 杜煦1 谢骞1 刘忠2△.化疗在中晚期非小细胞肺癌患者中对淋巴细胞亚群影响分析[J].现代生物医学进展英文版,2012,12(19):3657-3659. |
| 化疗在中晚期非小细胞肺癌患者中对淋巴细胞亚群影响分析 |
| Chemotherapy in Advanced Non-small Cell Lung Cancer Analysis ofLymphocyte Subsets |
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| DOI： |
| 中文关键词: 化疗 中晚期非小细胞肺癌 淋巴细胞亚群 |
| 英文关键词: Chemotherapy In advanced non-small cell lung cancer Lymphocyte subsets |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨化疗在中晚期非小细胞肺癌患者中对淋巴细胞亚群的影响。方法：随机抽取本院收治的60 例中晚期非小细胞肺
癌患者编为实验组进行化疗，另选取同期体检的50 例健康志愿者作为对照组。随访12 月-15 月，采用流式细胞仪技术分别对两
组外周血淋巴细胞亚群进行检测计数。结果：两组间相比，实验组患者的CD3+、CD4+、NK 细胞的数量以及CD4+/CD8+ 比值均低
于对照组(P<0.05)，而CD8+ 细胞的比例却高于对照组。化疗后CD3+、CD4+、CD4+/CD8+、NK 均较化疗前升高(P<0.05)，但CD8+ 不
变(P>0.05)。结论：应用化疗治疗中晚期非小细胞肺癌，可明显改善患者的免疫功能。 |
| 英文摘要: |
| Objective: To evaluate chemotherapy in advanced non-small cell lung cancer patients on the lymphocyte subsets.
Methods: 60 randomly selected hospital treated patients with advanced non-small cell lung cancer chemotherapy prepared for the
experimental group, select the same period another examination of 50 healthy volunteers as control group. Follow-up 6 to 12 months,
respectively, using flow cytometry in peripheral blood lymphocyte subsets of both groups were detected count. Results: Compared
between the two groups, experimental group were CD3+, CD4+, NK cell number and CD4+ / CD8+ ratio were lower than the control group
(P <0.05), while the proportion of CD8+ cells was higher. After chemotherapy, CD3+, CD4+, CD4+ / CD8+, NK higher than those before
chemotherapy (P<0.05), but CD8 + unchanged (P>0.05). Conclusion: Chemotherapy for advanced non-small cell lung cancer can
significantly improve the patient's immune function. |
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