| 黎功炳1 雷宁2 覃树勇1 龙军1△ 陈德书1 易伟1.乌灵胶囊对抑郁大鼠脑组织中乙酰化H3 及5-HTT、TH 表达的影响[J].现代生物医学进展英文版,2012,12(19):3642-3644. |
| 乌灵胶囊对抑郁大鼠脑组织中乙酰化H3 及5-HTT、TH 表达的影响 |
| The Effect ofWuling Capsule on the Expression of Acelyl Histone H3,5-HTT and TH in the Brain Tissue of Depressed Rats |
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| DOI： |
| 中文关键词: 抑郁 5-HTT TPH 乌灵胶囊 组蛋白H3 |
| 英文关键词: Athymia 5-HTT TPH Wuling capsule Histone H3 |
| 基金项目: |
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| 中文摘要: |
| 目的：观察乌灵胶囊对抑郁大鼠脑组织中乙酰化组蛋白H3 及5- 羟色胺受体（5-HTT）、酪氨酸羟化酶(tyrosine hydroxylase ,
TH)表达的影响。方法：SD 大鼠随机分为对照组、模型组及乌灵胶囊低、高剂量组。取大鼠脑组织，分别采用实时荧光定量PCR 法
和western blot 法检测脑组织中乙酰化组蛋白H3、组蛋白H3，5-HTT、TH 蛋白和mRNA 的表达。结果：乌灵胶囊明显增强大鼠脑
组织中乙酰化组蛋白比例和5-HTT、TH 蛋白和mRNA 的表达（P<0.05）。结论：乌灵胶囊治疗抑郁症的机制可能与升高脑组织乙
酰化组蛋白含量，从而促进5-HTT、TH 的表达有关。 |
| 英文摘要: |
| Objective: To observe the effect of Wuling capsule on the expression of acelyl histone H3, 5-HTT and TH in the brain
tissue of depressed rats. Methods: Rats were divide into control, model and two doses groups of Wuling capsule. Contents of acelyl
histone H3, histone H3, 5-HTT and TH mRNA and protein in he brain tissue of depressed rats were measured by realtime RT-PCR and
western blot methods, respectively. Results: Wuling capsule could increase the expression of acelyl histone H3, 5-HTT and TH mRNA
and protein in the brain tissue of depressed rats. Conclusion: Wuling capsule could cure athymia, this maybe concerned with its effect on
acelyl histone H3, 5-HTT and TH expression. |
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