| 金东岭王蕾时志民王广邑席丰.肥大细胞及类胰蛋白酶在人甲状腺肿瘤组织中的表达
及其与微血管密度的关系[J].现代生物医学进展英文版,2012,12(19):3639-3641. |
| 肥大细胞及类胰蛋白酶在人甲状腺肿瘤组织中的表达
及其与微血管密度的关系 |
| Correlation between Mast Cell and Tryptase Expression and MicrovesselDensity in Human Thyroid Tumor |
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| DOI： |
| 中文关键词: 甲状腺肿瘤 肥大细胞 类胰蛋白酶 微血管密度 |
| 英文关键词: Mhyroid neoplasms Mast cell Tryptase Microvessel density |
| 基金项目:河北省科技支撑项目（11276103D-31） |
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| 中文摘要: |
| 目的：探讨肥大细胞(mast cell，MC)及类胰蛋白酶(tryptase)与甲状腺肿瘤微血管密度(microvessel density,MVD)的相关性及其
对甲状腺癌发生发展的影响。方法：采用甲苯胺蓝组织化学染色和PV 免疫组织化学染色对116 例甲状腺癌、56 例甲状腺腺瘤和
10 例正常甲状腺组织中MC 和tryptase 及其CD31 的表达进行了检测；对MC 和tryptase 与MVD 的关系进行了统计学分析。结
果：甲状腺肿瘤中MC 的数量和tryptase 阳性表达高于正常甲状腺，而且与肿瘤的类型有关(P＜0.01)；Spearman 等级相关分析显
示各组甲状腺组织MC 数量和tryptase 表达与MVD 呈正相关(r=0.900，r=0.636，P＜0.05)。结论：MC 及其分泌的tryptase 有促进
血管新生的作用，因而可促进甲状腺肿瘤的浸润和转移。 |
| 英文摘要: |
| Objective: To investigate the correlation between the expression of mast cell (MC) as well as tryptase and
microvessel density (MVD) in in human thyroid tumor. Methods: Compare with and study the expression of MC, tryptase and CD31
which were examined by histochemistry and PV immunohistochemistry in 116 cases of thyroid carcinoma, 56 cases of thyroid adenoma,
10 cases of normal thyroid tissues; and analyzed the correlation of the MC, tryptase expressions and the MVD. Results: The number of
MC and the expression of tryptase in thyroid tumor tissues were higher than that in normal thyroid, and the number of MC and the
expression of tryptase was correlated with the type of tumor(P＜0.01). Spearman rank correlation analysis showed that the number of MC
was positively correlated with the MVD in the thyroid tissues (r=0.900，r=0.636，P＜0.05). Conclusions: The MC and tryptase may
promote to the angiogenesis of thyroid tumor, and so may promote invasion and metastasis of the thyroid tumor. |
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