孙红梅马晔陈方徐良德△.初探E2F1 对基因组内跨膜信号转导基因的调控作用[J].现代生物医学进展英文版,2012,12(19):3614-3617. |
初探E2F1 对基因组内跨膜信号转导基因的调控作用 |
Study on the E2F1 on Key Trans-membrane Signal Transduction Genes inGenome Regulation |
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DOI: |
中文关键词: 转录调控 离子通道 G 蛋白偶联受体 组织特异性 富集分析 |
英文关键词: Transcription regulation Ion channels G-protein coupled receptors Tissue specificity Enrichment analysis |
基金项目:黑龙江省教育厅科学技术研究项目(12511273) |
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中文摘要: |
目的:从基因组全局性角度研究E2F1 对包括离子通道和G 蛋白偶联受体在内的重要的跨膜信号转导基因的调控作用。方
法:对从TRED 和IUPHAR 获取的E2F1 靶基因数据和基因组离子通道及G 蛋白偶联受体基因数据进行数据联配,获取E2F1 调
控的离子通道基因(ICG)和G 蛋白偶联受体基因,并对调控基因进行家族富集性分析和组织特异性分析。结果:发现E2F1 对7 个
ICG 具有调控作用,且具有钾离子通道富集性,调控的离子通道基因具有心脏、脑、消化系统组织表达特异性。获得的11 个受
E2F1 调控的G 蛋白偶联受体基因家族富集性不明显,组织特异性表达不一致。结论:E2F1 可能通过对钾离子通道基因的表达调
控,实现对相应组织的作用机理影响,相应调控作用的紊乱也将导致心脏、脑或消化系统疾病,但难以确定E2F1 对GPCR 的调控
作用效果。 |
英文摘要: |
Objective: Our study told about E2F1 regulation on the important trans-membrane transduction genes from the point of
genome. Methods: We use TRED web service and IUPHAR database to realize E2F1 target genes, ion channel genes and
G-protein-coupled receptor genes extraction. We achieve E2F1 regulation signal transduction genes by data alignment. Then, we
introduce tissue-specific analysis and gene family enrichment analysis into the regulation data. Results: We find 7 ICG genes regulated by
E2F1 significantly enrich in potassium ion channels, while these genes have a high heart, brain and digestive system tissue expression.
E2F1 regulation of 11 GPCR genes did not show significant enrichment of family, and the tissue-specific expression is not clear.
Conclusions: E2F1 maybe affect the cell physics such as cardiac muscle cell by the regulation of potassium channels, and lead to the
heart, brain or digestive system diseases. |
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