| 刘昊1 张海燕1,2 宋伟1 芦乾1 李芳1 杨明1,3.京尼平苷的抗血栓基础研究[J].现代生物医学进展英文版,2012,12(19):3601-3604. |
| 京尼平苷的抗血栓基础研究 |
| Basic Research about Antithrombotic Effect of Geniposide |
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| DOI： |
| 中文关键词: 京尼平苷 抗血栓 纤溶 凝血时间 出血时间 |
| 英文关键词: Geniposide Antithrombotic Fibrinolytic Clotting Time Tail Transection Bleeding Time |
| 基金项目:国家自然科学基金项目（2009ZX09103-393） |
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| 中文摘要: |
| 目的：明确京尼平苷和京尼平的抗血栓和纤溶的作用效果。方法：用旁路循环血栓形成模型和颈总动脉血栓模型，测定CT、
BT、PRT、PT，全血溶栓，计算血栓形成抑制率。结果：试验表明，京尼平苷及其苷元能显著延长凝血、出血时间，减少两个血栓模型
的血栓重量，京尼平苷高剂量组与阳性药组相比，溶栓作用具有显著性差异（P<0.05），优于阳性药；京尼平、京尼平苷抗凝血及抗
血栓作用与阿司匹林组相比无显著差异（P>0.05）。结论：实验表明中药栀子能延长凝血和出血时间，可能有一定的抗血栓和溶栓
作用。 |
| 英文摘要: |
| Objective: To make sure the antithrombotic and fibrinolytic effect of geniposide and genipin. Methods: The model of
bypass loop thrombosis and carotid artery thrombosis were used to determine CT, BT, PRT, PT and weight of thrombus, then calculated
the rate of thrombosis inhibition. Results: Tests showed that geniposide and genipin could remarkably extend time of blood coagulation
and hemorrhage and reduce weight of thrombus. Compared with positive drug group(aspirin) genipin and geniposide high dose group had
significant difference (P<0.05) on anticoagulation and antithrombotic function. Geniposide low dose group had no significant difference
on thromblytic activity and antiplatelet aggregation compared with aspirin group (P>0.05). Conclusion: Geniposide and its aglycon might
have antithrombotic and fibrinolytic function. |
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