| 忻志祥1 王大伟2 盛畅2 徐晨3 鲁军1.磷酸二酯酶5（PDE5）在人增生前列腺移行带中的表达及分布[J].现代生物医学进展英文版,2012,12(18):3538-3540. |
| 磷酸二酯酶5（PDE5）在人增生前列腺移行带中的表达及分布 |
| XIN Zhi-xiang1, WANG Da-wei2, SHENG Chang2, XU Chen3, LU Jun |
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| DOI： |
| 中文关键词: 磷酸二酯酶5 前列腺增生 免疫组化 |
| 英文关键词: Phosphodiesterase 5 Benign Prostatic Hyperplasia Immunohistochemistry |
| 基金项目:浦东新区科技发展基金创新资金(PKJ2009-Y-29) |
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| 中文摘要: |
| 目的：探讨磷酸二酯酶5 在人前列腺移行带组织中的表达与分布。方法：应用免疫组化SP 法，选择前列腺增生患者34 例，
检测PDE5 表达及分布。结果：34 例标本中PDE5 均呈阳性表达。PDE5 在前列腺移行带的腺组织上皮普遍呈中等表达，间质部分
弱表达。结论：PDE5 在人增生前列腺组织中分布，但分布不均，表明不同PDE5 可能行使不同的功能。 |
| 英文摘要: |
| Objective: To investigate the Expression and Distribution of Phosphodiesterase 5 (PDE5) in the transitional zone of
Benign Prostatic Hyperplasia. Methods: The immunohistochemical SP method was used to detect the expression of PDE5 in the transitional
zone of Benign Prostatic Hyperplasia. Results: All sections were immunopositive for PDE5. The immnuointensity of PDE 5 was
relatively moderate in the epithelium of glandular structures. In contrast, PDE5 showed immunoactivity in the fibromuscular stroma but
its immnuointensity was faint. Conclusion: PDE5 is widely distributed in the transitional zone of Benign Prostatic Hyperplasia, but the
distri- bution is not even, indicating that different PDE5 may execute the different functions. |
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