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目的：探讨血尿酸（SUA）水平与冠状动脉病变程度的关系。方法：将268 例疑似冠心病（CHD）患者，经冠状动脉造影分为冠心病组198 例和非冠心病组70 例；冠心病组又分为单支病变组80 例，双支病变组56 例，三支病变组62 例。分别检测各组研究对象血尿酸含量，同时记录年龄、性别、吸烟、高血压、糖尿病、血尿酸及冠状动脉造影结果，分析血尿酸与已知冠心病主要危险因素、冠状动脉病变程度的相关性。结果：冠心病组血尿酸水平（395.35±84.40）μmol/L，显著高于非冠心病组（282.20±66.68） μmol/L（P＜0.05）。单支病变组（338.48±77.36）μmol/L、双支病变组（399.62±84.36）μmol/L、三支病变组（445.16±92.20）μmol/L，血尿酸水平呈递增趋势，各组之间的差异有统计学意义。结论：血尿酸水平可反映冠状动脉病变严重程度。降尿酸治疗有望成为心血管疾病防治的一种新途径。

英文摘要:

Objective: To explore the association between serum uric acid (SUA) level and coronary lesion severity. Methods: The study group consisted of 268 consecutive coronary heart disease (CHD) patients undergone coronary angiography. There were 198 cases diagnosed as CHD and 70 were not. The CHD group was divided into three subgroups included single-branch (80 cases), double-branch (56 cases) and three-branch (62 cases) according to the scope of pathological changes. Serun uric acid was determined. The relative factors of CHD, such as age, gender, smoking, hypertension, diabetes and serum uric acid were recorded. We observed the correlation among SUA, known main risk factors for CHD and the severity of coronary lesions. Results: The SUA level of CHD (395.35±84.40) μmol/L was significantly higher than that of the non-CHD group (282.20±66.68) μmol/L ( P <0.05).There was a trend of increase of SUA level in the single-branch subgroup (338.48±77.36) μmol/L, double-branch subgroup (399.62±84.36) μmol/L, three-branch subgroup (445.16±92.20) μmol/L. There was significant difference between the three groups (P < 0.05). Conclusions: The level of the SUA could reflect the severity of coronary artery lesion. Lowering SUA could become a new way for cardiovasular disease prevention.

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