| 张新风1 王鹏来1△ 刘超1 刘宗响1 程庆涛1 袁晟2.骨诱导无机材料BAM 修复牙种植体周围骨缺损的实验研究[J].现代生物医学进展英文版,2012,12(18):3469-3472. |
| 骨诱导无机材料BAM 修复牙种植体周围骨缺损的实验研究 |
| Experimental Study about BAM Osteoinduction Calcium Phosphate Ceramicin Repairing the Bone Defect around Dental Implant |
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| DOI： |
| 中文关键词: 骨诱导生物陶瓷 牙种植体 骨缺损 体内骨组织工程 |
| 英文关键词: Osteoinductive calcium phosphate ceramics (OICPC) Dental implant Bone defect Bone tissue engineering in vivo |
| 基金项目:江苏省徐州市科技局计划项目(XZZD0904) |
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| 中文摘要: |
| 目的：评价骨诱导磷酸钙生物陶瓷（BAMOICPC）与可吸收胶原膜（BME-10X 医用胶原膜）在牙种植体周围骨缺损中的修复
能力。方法：在兔股骨上植入羟基磷灰石涂层BLB 种植体，然后在其侧壁制造高4 mm、宽3 mm、深2 mm 的骨缺损。对照组为单
纯侧壁骨缺损，实验A 组骨缺损区仅覆盖BME-10X 膜，B 组骨缺损区植入BAMOICPC，C 组骨缺损区植入BAMOICPC 并加盖
BME-10X 膜。于术后6 个月取带种植体的骨段，通过HE 染色和扫描电镜(SEM)分析。结果：对照组骨缺损区种植体表面见纤维包
裹，实验A 组骨缺损边界区少许骨质移行覆盖，实验B 组下半部分缺损区新生骨覆盖。C 组新生骨完全覆盖骨缺损区，且较B 组
硬度高，扫描电镜见与种植体结合更紧密。组织学观察B、C 两实验组新生骨均可见比较成熟的哈弗氏管系统。结论：骨诱导磷酸
钙生物陶瓷BAMOICPC 是一种较理想的骨替代材料, 联合运用胶原膜修复种植体周骨缺损效果佳。 |
| 英文摘要: |
| Objective: To evaluate the ability of BAM osteoinductive calcium phosphate ceramic (BAMOICPC) with absorbable
collagen membrane (BME-10X medical collagen membrane) in repairing the bone defect around dental implant. Methods: BLB implants
coated by hydroxyapatite (HA) were implanted in femur of rabbit. Standard opening bone defect on one side of implant (4mm in height,
3mm in width,2mm in thickness)was made. In the control group, the side wall bone defect was open. In the experimental group A, the
side wall bone defect was covered simply by BME-10X collagen membrane. In the experimental group B, BAMOICPC were implanted
on the bone defects. In the experimental group C, BAMOICPC were implanted on the bone defects and covered with BME-10X collagen
membrane. On the 6th postoperative month, animals were killed and sampled. The bone with the implant segment were analyzed by HE
staining and scanning electron microscopy (SEM). Results: In the control group, the surface of implants in the area of bone defect were
wrapped by fibers. In group A, a little bone covered the border of bone defect. The experimental bone defects in group B were partially
covered by new bone.In group C, the bone defects were completely covered by new bone. Compared with group B, the new bone in
group C was high hardness, and combined with the implant more tightly by SEM observation.The mature haversian canals system were
observed both in B and C experimental groups by histology methods. Conclusion: BAM osteoinductive calcium phosphate ceramics
(BAMOICPC) is an ideal bone substitute material. Combined with collagen membrane, BAMOICPC repaired the bone defect around
dental implants more excellently. |
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