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目的：探讨磷酸钙骨水泥（CPC）与富血小板血浆（PRP）混合物应用于拔牙后种植位点保存的可行性。方法：拔除6 只犬下颌双侧第三切牙与一侧第一切牙，并于每只犬的3 个拔牙窝颊舌侧骨壁分别制造2 mm×2 mm×3 mm 缺损，随机在两个牙槽窝内分别植入CPC 或CPC 与PRP 的混合物，第三个不加处置作对照，在术后4、8、12 周各处死两只动物，行大体、X 线、显微镜观察，比较各组的新骨生成情况。结果：术后4 周时CPC/PRP 混合物组骨形成早于其他组，8、12 周时CPC/PRP 混合物组新骨生成明显优于CPC 组和对照组。结论：CPC 混合PRP 可促牙槽窝新骨生成并能保证成骨的高度和颊舌向宽度，从而为后期种植义齿修复提供了必要的条件。

英文摘要:

Objective: To study the feasibility of application of calcium phosphate cement (CPC) and platelet rich plasma (PRP) complex in implant site preservation after tooth extraction. Methods: The mandibular bilateral third incisors and the first incisor of one side of six dogs were extracted. For each dog, the edentulous regions of 2mm×2mm×3mm size were created, respectively, on the buccal and lingual bone walls. CPC and CPC/PRP complex were randomly implanted into two of the alveolar nest and no operation with the third one as control group. Six dogs were killed respectively on 4 weeks, 8 weeks and 12weeks after operation, two dogs each time. The clinical check, radiology and bone histomorphology analysis were conducted to compare the status of new bone formation. Results: The bone formation of CPC/PRP complex group is earlier than the others on 4 weeks after operation. On 8 and 12weeks after operation, the new bone formation of CPC/PRP complex group is superior to CPC group and control group too. Conclusions: CPC/PRP complex promotes new bone formation of alveolar fossa and guarantees bone height and buccolingual width, which provides necessary conditions for denture implantation later.

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