李威吴昊张彤△.III 型干扰素的抗肿瘤作用*[J].现代生物医学进展英文版,2012,12(17):3370-3373. |
III 型干扰素的抗肿瘤作用* |
The Anti-tumor Effects of Type III Inteferons* |
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DOI: |
中文关键词: III 型干扰素 干扰素lambda 抗肿瘤 |
英文关键词: Type III Interferon Interferon lambda Anti-tumor activity |
基金项目:北京市属高等学校人才强教计划资助项目(PHR201007112);艾滋病研究北京市重点实验室(BZ0089) |
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中文摘要: |
III 型干扰素(IFNλs)是干扰素家族中最新的一组成员。他们的很多生物学活性与临床上应用广泛的IFNα/β 十分相似,但
是他们所结合的受体与IFNα/β 迥异。III 型干扰素的毒副作用显著小于IFNα/β,且抗肿瘤作用明显。本文回顾了近年来对III 型
干扰素抗肿瘤功能研究的最新进展。 |
英文摘要: |
Type III interferons (IFNλs) are the latest members of interferon family and share many biological activities with
IFNα/β, but conduct signals through distinct receptor complexes. They have less severe side effects than IFNα/β and possess potent
anti-tumor effects. Here we review the latest advances of studies upon the anti-tumor potentials of type III interferons. |
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