| 薛满1 马春利1 梁宽1 田娟1 李鑫2.孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床疗效及安全性研究[J].现代生物医学进展英文版,2012,12(17):3317-3319. |
| 孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床疗效及安全性研究 |
| The Clinical Effect and Safety of Montelukast Sodium Treatmentof Cough Variant Asthma in Children |
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| DOI： |
| 中文关键词: 小儿 变异性哮喘 孟鲁司特钠 安全性 |
| 英文关键词: Children Cough variant asthma Montelukast Sodium Safety |
| 基金项目:宝鸡市人民医院儿科 |
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| 中文摘要: |
| 目的：探讨孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床疗效及安全性。方法：166 例小儿咳嗽变异性哮喘患者随机分为对照
组和观察组，每组83 例，对照组给予布地奈德联合特布他林雾化吸入，观察组在对照组的基础上加服孟鲁司特钠，治疗4 周后对
两组的临床疗效进行评价。结果：观察组临床总有效率显著高于对照组(91.57%VS80.72%，P<0.05)；观察组患者哮喘持续时间、咳
嗽消失时间及肺部哮鸣音消失时间均快于对照组(P<0.05)；治疗后两组患者FEV1 和PEF%显著升高(P<0.05)，观察组升高更为明
显(P<0.05)，两组均无严重不良反应。结论：孟鲁司特钠治疗小儿咳嗽变异性哮喘可有效改善患者的肺通气功能和缓解临床症状，
是治疗该病的可靠方法。 |
| 英文摘要: |
| Objective: To explore the clinical effect and safety of Montelukast Sodium treatment of cough variant asthma in
children. Methods: 166 cases of cough variant asthma in children were divided into control group and observation group, each for 83
cases. The patients of control group were given Terbutaline combined with Budesonide spray inhalation, and the patients of observation
group were given Montelukast Sodium on the basis of control group. After 4 weeks, the clinical effect was evaluated. Results: The rate of
effect was higher in observation group than in the control group (91.57%VS80.72%，P<0.05). The asthma duration time, cough and
wheezes disappeared time were faster in observation than in the control group (P<0.05). After treatment, FEV1 and PEF% were
significantly increased (P<0.05), the observation group was better than control group (P<0.05), there were no severe side effects.
Conclusion: Montelukast Sodium can improve pulmonary ventilation function and relieve patients symptoms, it is a reliable methods for
treatment of cough variant asthma in children. |
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