| 王戈唐启盛△ 李小黎赵瑞珍李冬梅.脑卒中后大鼠海马形态学演变趋势及中药的干预作用研究[J].现代生物医学进展英文版,2012,12(17):3239-3243. |
| 脑卒中后大鼠海马形态学演变趋势及中药的干预作用研究 |
| Hippocampus Morphological Evolution Trend and Interventional Effectsof Chinese Medicinal in Rats with Post Stroke |
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| DOI： |
| 中文关键词: 脑卒中 海马 形态学 演变趋势 颐脑解郁方 |
| 英文关键词: Stroke Hippocampus Morphological Evolution trend Yinaojieyu Formula |
| 基金项目:国家自然科学基金资助项目(30973740，81173231)；国家中医药管理局中医药行业专项(20080709)；北京中医药大
学创新团队（2011-CXTD-26）；北京中医药大学自主选题项目（2011-JYBZZ-JS126） |
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| 中文摘要: |
| 目的：观察脑卒中后大鼠海马的形态学演变趋势及颐脑解郁方对其的干预作用。方法：雄性Wistar 大鼠随机分为正常组、假
手术组、MCI 组、中药组、西药组、PSD 组和VD 组。采用同种系微栓子体外注入法制备MCI 模型；PSD 组术后7 d 予21 d 慢性不
可预知的温和应激加孤养复制PSD 模型；VD 组术后28 d 经水迷宫筛选后进入实验。假手术组、中药组及西药组分别予蒸馏水、
颐脑解郁方、尼莫地平干预给药4 周。于第1、2、4 周光镜下分析海马的形态学结构变化。结果：MCI 组海马锥体细胞数量显著减
少，细胞排列不整齐。PSD 组及VD 组锥体细胞数量显著减少，胞体不同程度缩小、核固缩、核碎裂、核溶解，细胞排列不整齐，且
呈进行性发展。中药组锥体细胞缺失较少，细胞排列整齐，核仁明显，西药组细胞变性有所改善，部分细胞核固缩，不如中药组改
善明显。结论：颐脑解郁方可能通过益肾调气的主治功效改善Papez 回路的病理改变，阻断病情的进一步发展。 |
| 英文摘要: |
| Objective: To investigate the Hippocampus morphological evolution trend and Yinao Jieyu Formula side of their
intervention effects after stroke in rats. Methods: Male Wistar rats were randomly divided into normal group, sham operation group of MCI
Group, the Chinese Medicines, western medicine group, the PSD group VD group. The same germ-line micro-emboli in vitro injection
was prepared by MCI model; the PSD group after 7 d to 21 d of chronic unpredictable mild stress plus solitary housed and PSD model;
the VD group after 28 d after water maze screening to enter the experimental. Sham group, the Chinese medicine group and WM group
were given distilled water. Yinao Jieyu Formula nimodipine intervention administered four weeks. 1, 2 and 4 weeks under the light
microscope analysis of morphological structural changes in the hippocampus. Results：Hippocampal pyramidal cells in MCI group reduc
the irregular arrangement of cells. The number of pyramidal cells in PSD group and VD group reduced significantly, and soma has different
level reduced, pyknosis, karyorrhexis and karyolysis. Pyramidal cells arranged irregularly, and got worse. Chinese medicine group
showed that pyramidal cell loss less, and arranged regularly, nucleolus can be seen clearly. Degeneration of pyramidal cells in western
medicine group improved,pyknosis in some of pyramidal cells, and not as good as Chinese medicine group. Conclusions：YinaoJieyu
Formula iPapez loop pathological change and block the progress of the disease by reinforcing kidney and regulating gas primary. |
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