| 罗颂明郭霞珍刘晓燕△.气温突变对高血压大鼠心梗发病及心肌损害的影响[J].现代生物医学进展英文版,2012,12(17):3224-3227. |
| 气温突变对高血压大鼠心梗发病及心肌损害的影响 |
| The Affect of Incidence of Myocardial Infarction and MyocardialDamage in Hypertensive Rats Induced by Sudden Risingand Dropping of Temperature* |
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| DOI： |
| 中文关键词: 急性心肌梗塞 心肌损害 大鼠 |
| 英文关键词: Acute myocardial infarction Myocardial damage Rats |
| 基金项目:北京中医药大学自主选题资助项目（JYBZZ-JS020） |
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| 中文摘要: |
| 目的：探索气温突变对高血压大鼠心梗发病及心肌损害的影响。方法：给予肾动脉半结扎大鼠一次维生素D3 70 U/kg 体重腹
腔注射，22℃环境下饲以高脂饲料。10 周后随机分为S、J 和D 三组，S 组予以30 分钟内升温至40℃处理，J 组予以30 分钟内降
温至4℃的处理，D 组为对照组。结果：S 组大鼠急性心梗发病率为59.09%，J 组大鼠发病率为26.32%，D 组发病率为28.57%，S 组
大鼠以及J 组大鼠血清肌钙蛋白、肌酸激酶、谷草转氨酶、肌酸激酶同工酶、乳酸脱氢酶含量（P<0.05）均明显高于D 组大鼠，S 组
与D 组大鼠肌钙蛋白等含量（P>0.1）无显著差异。结论：气温骤升、骤降均能加重造成心肌损害，但夏季气温骤升所造成的急性心
梗发病率高于气温的骤降。 |
| 英文摘要: |
| Objective: To explore the affect of incidence of myocardial infarction and myocardial damage in hypertensive rats
induced by sudden rising and dropping of temperature. Methods: Renal artery half ligated rats were treated with one intramuscular
intraperitoneal injection of vitamin D3 (7*105U/kg) followed by high cholesterol diet in 22℃. After 10 weeks, divided all rats into
random S, J, D groups. The S group is induced by rising to 40℃ in 30 minutes, the J group is induced by dropping to 4℃ in 30 minutes,
and the D group is without induced. Results: The incidence of the S group is 59.09%, the incidence of the J group is 26.32%, and the D
group is 28.57%. The content of Troponin, Creatine Kinase, creatine Kinase-MB, Aspartate aminotransferase, Lactate dehydrogenase in
the S group and the incidence of the J group is higher than in the D group(P<0.05). and the content had no significant differences between
the S group and the J group(P>0.1). Conclusions: The rising and dropping of temperature can create myocardial damage, and the rising of
temperature can make more pathogenesis than the dropping of temperature. |
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