| 姜利军1 周晓曦1 李钦璐1 于飞2 黄亮1 马全富2 周剑峰1 曹阳1△.斑马鱼Gfi-1 基因结构和功能分析[J].现代生物医学进展英文版,2012,12(17):3213-3216. |
| 斑马鱼Gfi-1 基因结构和功能分析 |
| Zebrafish Gfi-1 Genetic Structure and Function Analysis |
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| DOI： |
| 中文关键词: 斑马鱼 Gfi-1 基因 生物信息学 |
| 英文关键词: Zebrafish Gfi-1 Bio-informatics |
| 基金项目:国家自然科学基金青年基金（81001049） |
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| 中文摘要: |
| 目的：研究斑马鱼Gfi-1 基因在物种间进化的保守性和功能分析。方法：运用生物信息学方法分析斑马鱼Gfi-1 基因结构
特征和保守性等。结果：斑马鱼Gfi-1 基因在蛋白水平与小鼠、人高度保守；分析斑马鱼和人的Gfi-1 基因外显子、内含子和ATG
起始、终止密码子也具有高度相似性；从进化树分析斑马鱼Gfi-1 基因与人、小鼠、犬、猴等在进化上高度保守；分析斑马鱼、人、小
鼠Gfi-1 基因在染色体上的位置和相邻基因，显示出惊人的相似性。结论：斑马鱼Gfi-1 基因在进化上高度保守，为脊椎动物保守
基因，为其后续在造血系统和造血微环境方面的研究提供了理论支持和铺垫。 |
| 英文摘要: |
| Objective: To study the conservation of zebrafish Gfi-1 gene during evolution of species. Methods: We analyze the
structural characteristics and conservation of Gfi-1 gene by the bio-informatics. Results: Zebrafish Gfi-1 gene was highly conversative
between mouse and human being at protein level. Gfi-1 gene structure of extron, intron, ATG intiator, and stop codon was similar between
zebrafish and human being. Zebrafish Gfi-1 gene was highly conservative in human being,mouse, dog, monkey phylogenetic tree.
Syntenic arrangement around the Gfi-1 gene locus on zebrafish chromosome 6 showes prominent similarity to the locus of its human
ortholog on chromosome 1 and its mouse ortholog on chromosome 5. Conclusions: Zebrafish Gfi-1 gene is conservative during evolution
and an conservative gene in vertebrates，it has provided theoretical support and foundation for the following research in hematopoietic
system and hematopoietic microenvironment. |
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