| 毕琳琳缪珊王四旺△.蟾酥抗肿瘤有效成分的作用研究[J].现代生物医学进展英文版,2012,12(16):3185-3187. |
| 蟾酥抗肿瘤有效成分的作用研究 |
| Progress of Research on the Chemical Components of VenenumBufonis and its Antitumor Effects |
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| 中文关键词: 蟾酥 化学成分 诱导凋亡 抑制增殖 诱导分化 细胞周期阻滞 |
| 英文关键词: Venenum Bufonis Chemical component Induce apoptosis Inhibit proliferation Induce differentiation Cell cycle arrest |
| 基金项目:陕西省自然科学基金：脂蟾毒配基和人参皂苷Rg3 联合抗肿瘤作用机制研究（2010JQ4019） |
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| 中文摘要: |
| 蟾酥（Venenum Bufonis）一词源自《本草衍义》，为我国名贵的传统中药。其含有多种化学成分，具有镇痛、强心、升压、局麻、
抗炎和抗肿瘤等药理活性，临床应用广泛。蟾酥中抗肿瘤的有效成分为蟾毒配基类化合物，包括脂蟾毒配基、华蟾毒配基和蟾毒
灵等。抗肿瘤活性主要包括诱导肿瘤细胞凋亡、抑制肿瘤细胞增殖、诱导肿瘤细胞分化等。近年来，有关蟾酥中活性成分在抗肿瘤
方面的作用越来越成为国内外学者研究的热点。 |
| 英文摘要: |
| Venenum Bufonis, the name of which origin from the Canon of Chinese Materia Medica Ben Cao Yan Yi, is a rare
and valuable traditional Chinese medicine. It is widely applied in clinic, for it contains many chemical components and has functions in
analgesia, strong heart, boosting pressure, local anesthesia, anti-inflammatory and antitumor. The active antitumor component of venenum
bufonis is bufogenin compound, including bufogenin, cinobufagin, bufalin and so on. The antitumor activity mainly includes inducing
apoptosis of tumor cells, inhibiting the cell proliferation and inducing the cell differentiation. In recent years, the antitumor effects of
venenum bufonis and its active components has become research focus at home and abroad. |
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