| 滕皓1 周荣祥1△ 张钢1 张宗亮1 王鹏1 赵凯2.COX-2 与mPGES-1 在肾透明细胞癌中的表达及临床意义[J].现代生物医学进展英文版,2012,12(16):3141-3143. |
| COX-2 与mPGES-1 在肾透明细胞癌中的表达及临床意义 |
| Expression and Clinical Significance of Cyclooxygenase-2 and MicrosomalProstaglandin E2 Synthase-1 in Clear Cell Renal Cell Carcinoma |
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| DOI： |
| 中文关键词: 环氧合酶-2 膜结合型前列腺素E2 合成酶-1 肾透明细胞癌 免疫组织化学 |
| 英文关键词: Cyclooxygenase-2 Microsomal prostaglandin E2 synthase-1 Clear cell renal cell carcinoma Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨环氧合酶-2（COX-2）和膜结合型前列腺素E2 合成酶1（mPGES-1）在肾透明细胞癌组织中的表达及临床意义。方
法：采用免疫组化SP 法分别检测49 例肾透明细胞癌组织标本和21 例正常肾组织标本中COX-2 和mPGES-1 的表达。结果：
COX-2 在正常肾组织中的阳性表达率为4.8%，在肾透明细胞癌组织中的阳性表达率为53.1%（P<0.05）；mPGES-1 在正常肾组织
中的阳性表达率为4.8%，在肾透明细胞癌组织中的阳性表达率为40.8%（P<0.05）；COX-2 和mPGES-1 的高表达均与肾透明细胞
癌的病理分级和临床分期无相关性（P>0.05）；COX-2 和mPGES-1 在肾透明细胞癌中的表达呈正相关（P<0.05），r=0.5。结论：
COX-2 和mPGES-1 在肾透明细胞癌发生及发展过程中共同发挥重要作用；COX-2 和mPGES-1 可能成为肾透明细胞癌新的治疗
靶点。 |
| 英文摘要: |
| Objective: To explore the expression and clinical significance of cyclooxygenase-2 (COX-2) and microsomal
prostaglandin E2 synthase-1 (mPGES-1) in clear cell renal cell carcinoma. Methods: 49 cases of clear cell renal cell carcinoma tissues
specimens and 21 cases of normal renal tissues specimens were used to detect the expression and the clinicopathological features of
COX-2 and mPGES-1 in clear cell renal cell carcinoma by means of immunohistochemistry SP method. Results: COX-2 positive expression
rate in normal renal tissue was 4.8%. On the contrary, COX-2 positive expression rate in clear cell renal cell carcinoma was 53.1%
(P<0.05). mPGES-1 positive expression rate in normal renal tissue was 4.8%. On the contrary, mPGES-1 positive expression rate in clear
cell renal cell carcinoma was 40.8% (P<0.05). The overexpression of mPGES-1 and COX-2 was not correlated with the pathologic grading
and clinical staging of clear cell renal cell carcinoma (P>0.05). The expression of COX-2 was positively correlated with mPGES-1
(P<0.05), r=0.5. Conclusion: COX-2 and mPGES-1 might play crucial roles in the occurrence and development of clear cell renal cell
carcinoma in common; COX-2 and mPGES-1 may be the novel therapeutic targets for treatment of clear cell renal cell carcinoma. |
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