| 张伟星1 陈颖2 李百文1 李雷1 宛新建1.胆酸钠和依地酸二钠复合用药的溶石效果研究[J].现代生物医学进展英文版,2012,12(16):3115-3119. |
| 胆酸钠和依地酸二钠复合用药的溶石效果研究 |
| The Research of Stone Dissolution Effect in Sodium Cholateand Disodium Edetate |
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| DOI： |
| 中文关键词: 胆酸钠 依地酸二钠 胆管结石 溶石 胆汁 |
| 英文关键词: Sodium cholate Disodium edetate Bile duct stones Dissolution Bile |
| 基金项目:教育部博士点基金（新教师类）（2-0902） |
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| 中文摘要: |
| 目的：探讨胆酸钠和依地酸二钠不同摩尔比、胆汁中不同药物浓度、溶解时间与胆管结石溶石效果之间的关系。方法：设计
在一个月内胆汁中药物浓度为0.1%的、摩尔比分别为0:1、8:1、4:1、2:1、1:1、1:2、1:4、1:8 和1:0 的九个等级的胆酸钠和依地酸二钠
的溶石实验，摩尔比为1:1 的这两种溶石药物在胆汁中药物浓度为0、0.1%、0.2%、0.4%、0.8%、1.6%和3.2%的溶石实验，和摩尔比
1:1 的溶石药物在胆汁中浓度为0.1%的经过0、1、2、4、8、16、32 和64d 的溶石实验；评估这三个实验的各自溶石质量是否相等
（P<0.05 有显著性统计意义）。结果：胆汁中药物浓度、溶石时间相同时，单药依地酸二钠溶石效果比胆酸钠强，复合药物比单药效
果好，越靠近摩尔比为1:1 时的溶石能力越强，在摩尔比为1:1 时溶石能力最强；在相同时间、摩尔比为1:1 的复合药物中，药物浓
度越大，溶石能力越强；在有充足溶石药物的条件下，相同摩尔比、相同药物浓度，溶解的时间越长，溶石能力越强（P<0.05，有显著
性统计意义）。结论：胆酸钠和依地酸二钠摩尔比为1:1 时，复合药物具有最大的溶石效果；在有充足溶石药物的条件下，药物浓度
越大，溶解的时间越长，溶石能力越强 |
| 英文摘要: |
| Objective: To study the relationship between the dissolution effect of bile duct stones and the different molar ratio of
sodium cholate and disodium edetate, drug concentrations, and the time in the bile. Methods：To design the three dissolution experiments
that the total drug concentration was 0.1% in the bile within one month, and the molar ratio of sodium cholate and disodium edetate was
0:1,8:1,4:1,2:1,1:1 1:2,1:4,1:8 and 1:0; that the molar ratio was 1:1, and drug concentrations in the bile were 0, 0.1%, 0.2%, 0.4%, 0.8%,
1.6% and 3.2% in within one month; that that the molar ratio was 1:1, drug concentration was 0.1%, and the time were 0,1,2,4,8,16,32
and 64d.To assess the quality loss of stones in the three experiments was equal (P <0.05 statistical significance). Results：Tt the total drug
concentration of 0.1% in one month, disodium edetate dissoluted more stones than sodium cholate, and complex drugs dissoluted more
stones than a single agent, and the closer the molar ratio of 1:1, the stronger dissolution ability, the strongest was 1:1. At complex drug of
1:1 in one month, the higher the drug concentration, the stronger dissolution ability. In the conditions of sufficient dissolution drugs, the
total drug concentration of 0.1%, and the molar ratio of 1:1, the longer, the more the quality loss of stones (P<0.05, significant statistical
significance). Conclusion：When the sodium cholate and sodiumcholate was 1:1,the complex drugs have the strongest dissolution effect;
in the condition of sufficient dissolution drugs, the higher the drug concentration, the longer, the more the quality loss of stones. |
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