| 陈悦1 王永鹏1 宋纯1 刘放1 马思平1 张睿1 王辉1 徐宏勋2.直肠癌的淋巴结转移的危险因素[J].现代生物医学进展英文版,2012,12(16):3107-3111. |
| 直肠癌的淋巴结转移的危险因素 |
| Lymph Node Metastasis and Its Risk Factors in Rectal Cancer Running Head:Risk Factors of Lymph Node Metastasis |
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| DOI： |
| 中文关键词: 淋巴结转移 直肠癌 危险因素 |
| 英文关键词: Lymph node metastasis Rectal cancer Risk factors |
| 基金项目: |
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| 中文摘要: |
| 目的：本研究主要目的为确定直肠癌的淋巴结转移的危险因素。方法：通过对1250 例于2004 年-2008 年行直肠癌根治性切
除的患者进行单因素和多因素分析，以确定淋巴结转移相关的危险因素，同时对PT 分期和肿瘤大小之间的关系进行了相关性分
析。结果：直肠癌患者淋巴结转移发生率为41%。在单因素分析中，患者年龄(P=0.008)、肿瘤大小(P=0.003)、PT 分期(P<0.0019）以
及分化程度(P<0.001)和淋巴结转移相关。在多因素分析中，年龄（P=0.017，OR=0.988，95%可信区间：0.978-0.998）、PT 分期（P<0.
001，OR＝1.952，95%可信区间：1.656-2.302）和分化程度（P<0.001，OR＝3.697，95%可信区间：2.112-6.472）是淋巴结转移的独立因
素。结论：在直肠癌相关分析中，肿瘤的大小和PT 分期呈正相关。年龄、PT 分期和肿瘤分化程度是淋巴结转移的独立因素。在直
肠癌中，肿瘤的大小和PT 分期呈正相关。 |
| 英文摘要: |
| Objective: To identify risk factors of lymph node metastasis in rectal cancer. Methods: Data from 1250 patients with
rectal cancer who underwent radical resection from 2004 to 2008. Univariate and multivariate analysis were performed to identify risk
factors associated with lymph node metastasis. The relationship between pT stage and tumor size was analyzed by correlate analysis.
Results: The incidence of lymph node metastasis was 41.0% for patients with rectal cancer. In the univariate analysis, age (P=0.008), tumor
size(P=0.003), pT stage(P<0.001) and differentiation(P<0.001) were correlated with LNM. In multivariate analysis, only age(P=0.
017, OR=0.988, 95% confidence interval (CI): 0.978-0.998), pT stage (P<0.001, OR=1.952, 95% CI: 1.656-2.302) and differentiation
(P<0.001, OR=3.697, 95% CI: 2.112-6.472) were independent factors for lymph node metastasis. A positive association was found between
tumor size and pT stage by correlate analysis in rectal cancer. Conclusion: Age, pT stage and differentiation might be predictive
factors for lymph node metastasis. Tumor size and pT stage had positive correlation in rectal cancer. |
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