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目的：检测Twist 在胸腺上皮性肿瘤的表达及其与预后的关系。方法：应用免疫组织化学pv6000 法检测Twist 在87 例胸腺上皮性肿瘤（胸腺瘤71 例，胸腺癌16 例）中的表达情况，分析其与患者各项临床病理指标及预后的关系。结果：Twist 蛋白在胸腺癌的阳性表达（81.3 %）显著高于胸腺瘤组织（11.3 %）,其阳性表达的差异存在统计学意义(P<0.001），其在胸腺瘤各亚型之间表达的差异无统计学意义（P＞0.05）。Twist 阳性表达与胸腺上皮性肿瘤术后发生远处转移呈正相关关系（r=0.40，P=0.001）。Kaplan- Meier 生存分析显示Twist 阳性表达患者术后生存期低于Twist 阴性表达患者（P<0.001）。结论：检测Twist 蛋白表达情况对于鉴别胸腺瘤与胸腺癌可能有重要的参考价值, Twist 阳性表达可能与术后发生远处转移有关并影响患者术后生存期。

英文摘要:

Objective: To investigate the expression and significance of Twist in thymic epithelial tumor. Methods: We immunohistochemically investigated the relation between the expression and clinicopathological factors including prognsis in surgical specimens of thymic epithelial tumor in 87 patients including 71 patients with thymomas and 16 specimens of thymic carcinoma. Results: Among the 71 thymomas, 8(11.3%) cases were positive for Twist immunoexpression, and 13(81.3%) cases were positive in 16 thymic carcinoma. The expression of Twist was significantly higher in thymic carcinoma than in thymomas (P<0.001). The expression of Twist among subtypes of thymomas (A,AB, B1,B2,B3) is not statistically different （P>0.005）. The Twist expression was positively related with distant metastasis after operation (r=0.40, P=0.001). Kaplan-Meier analysis showed that the positive expression of Twist was significantly associated with lower survival rates of patients after operation (P<0. 001). Conclusion: Evaluation of Twist expression may have significant reference value to distinguish between thymomas and thymic carcinoma. The positive expression of Twist should be associated with the metastasis and survival in postoperative.

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