| 宫献文1 赵鑫1 李娅1 王文岚1 张学思2 郭庆军1 谢小萍1 任杰1
李金声1 常耀明1△.复合疲劳对大鼠不同组织矿物质代谢影响研究[J].现代生物医学进展英文版,2012,12(16):3012-3018. |
| 复合疲劳对大鼠不同组织矿物质代谢影响研究 |
| Effects of Induced Fatigue on the Levels of Selected Essential Elementsin the Blood and Tissues of Rats |
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| DOI： |
| 中文关键词: 疲劳 矿物质 微量元素 原子吸收分光光度法 |
| 英文关键词: Fatigue Minerals Trace elements FAAS |
| 基金项目:国家科技重大专项（2008ZXJ9009-005） |
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| 中文摘要: |
| 目的：研究复合疲劳大鼠血液、肌肉、肝脏和脑中矿物元素代谢变化的影响。方法：将30 只大鼠随机分为正常对照组、食物
限制组和复合疲劳组。经过5 天的实验干预后，提取动物的血液、腓肠肌、肝脏和脑，并利用原子吸收分光光度法测量各组织中的
钾（K）、钙（Ca）、镁（Mg）、铁（Fe）、锌（Zn）和铜（Cu）。结果：相对正常对照组和食物限制组，复合疲劳大鼠的肌肉、肝脏和脑中的K
（P<0.01）和肝脏中的Fe(P<005)明显升高，血液中的Cu(与正常对照组比较P<0.01,与食物限制组比较P<0.05)明显下降；与对照组
相比，复合疲劳大鼠的血液中的K 明显升高（P<0.05），血液中的Mg 和Zn（P<0.05），肌肉中的Ca、Mg 和Zn (PCa<0.05, PMg<0.05,
PZn<0.01),肝脏中的Ca 和Zn(PCa<0.01, PZn<0.05),以及脑中的Fe、Mg 和Zn(PFe<0.05, PMg<0.05, PZn<0.01)明显降低。结论：在
复合疲劳状态下，大鼠血液、肌肉、肝脏和脑中的K、Ca、Mg、Fe、Zn 和Cu 代谢发生变化，可能在疲劳的发生与缓解中发挥作用。 |
| 英文摘要: |
| Objective: To identify the changes of some selected elements in blood, skeletal muscle, liver, and brain in a rat model
with complex fatigue. Methods: 30 rats in the experiment were randomly divided into three groups: the control group, the food-restricted
group, the complex fatigued group. Blood and tissue samples were collected at the end of the 5-day and levels of potassium (K), calcium
(Ca), magnesium (Mg), iron (Fe), zinc (Zn), and copper (Cu) were measured with atomic absorption spectrophotometer. Results: Compared
with that in the control and food-restricted group, the concentrations of potassium in the skeletal muscle, liver, and brain (P<0.01),
the concentration of iron in the liver (P<005), were increased in the complex fatigued group, and the concentration of copper in the blood
(P<0.01, to the control, P<0.05, to the food-restricted) decreased in animals with complex fatigue; compared with that in the control
group, the concentration of potassium in the blood was increased in the complex fatigued group (P<0.05), the concentrations of magnesium
and zinc in the blood (P<0.05), the concentrations of calcium, magnesium, and zinc in the skeletal muscle (PCa<0.05, PMg<0.05,
PZn<0.01), the concentrations of calcium, and zinc in the liver (PCa<0.01, PZn<0.05), and the concentrations of iron, magnesium, and
zinc in the brain (PFe<0.05, PMg<0.05, PZn<0.01) were decreased in animals with complex fatigue. Conclusions: The metabolism of
potassium, calcium, magnesium, iron, zinc, and copper in blood, skeletal muscle, liver, and brain changed differently in rats with complex
fatigue, which indicated that these minerals may play some important role in the occurrence and relieving of fatigue. |
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