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随着关节韧带损伤发生率日益提高，人工材料植入重建韧带功能是重要治疗手段之一。植入后宿主细胞的趋向、黏附和迁移是人工材料在体内形成长期稳定生物连接的关键。以往研究集中于提高材料生物性，如增加材料亲水性、表面修饰、黏附适宜细胞以及复合细胞因子等，目前在张力环境下三维微孔结构对宿主细胞黏附、迁移、长入和分化影响的研究较少。本文拟以生物相容性良好的聚对苯二甲酸丁二醇酯（PET）材料作为载体，探讨在张力状态下新编PET 的结构、孔径大小和孔隙率对细胞迁移等细胞生物学行为影响的研究现状和未来发展。为这些研究的深入指明方向，也为PET 作为人工材料修复韧带损伤的临床应用奠定实验基础。

英文摘要:

As the joint ligament injury rate increasing，artificial materials implanted ligament reconstruction is an important feature of treatment. The trend, adhesion and migration of host cells after implantation is a key factor of artificial materials in the body forming a long-term stable of biological connections. Previous studies have focused on improving the biological material, such as increasing the hydrophilicity materials, surface modification, adhesion of suitable cell and composite cytokines, At present, there is few researches on three-dimensional porous structure under tension environment affecting the host cell adhesion, migration, growth and differentiation. This paper focuses on a good biocompatible Polyethylene terephthalate (PET) as a carrier, to explore the tension state of new PET structure, pore size and porosity on the behavior of cell migration and other cell biology studies the impact of present and future development. It indicates the direction of the depth of these studies, and establishes the basis of PET as a material for the repair ligament damage in human clinical application.

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