| 张琳1 李秀1 孙丽岩2 孔德军1△.靶定IL-17 治疗类风湿关节炎研究进展[J].现代生物医学进展英文版,2012,12(15):2971-2973. |
| 靶定IL-17 治疗类风湿关节炎研究进展 |
| The Research Advancement of Targeting IL-17 on the Treatment forRheumatoid Arthiritis |
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| DOI： |
| 中文关键词: IL-17 Th17 细胞 自身免疫性疾病 类风湿关节炎 |
| 英文关键词: IL-17 Th17 cell Autoimmune diseases Rheumatoid arthritis |
| 基金项目: |
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| 中文摘要: |
| IL-17 作为前炎症因子参与类风湿关节炎，系统性红斑狼疮等自身免疫性疾病的病理过程。它主要由CD4+T 细胞的一个亚
群--Th17 细胞分泌释放。目前，IL-17 在类风湿关节炎的病理过程中的作用引起了医学界广泛的关注，抗IL-17A 抗体已经生产并
进入临床实验，用于治疗类风湿关节炎、银屑病关节炎等疾病。但其在类风湿关节炎病理过程中的作用尚需进一步研究，其有效
性亦尚需进一步探讨。本文主要针对IL-17 家族的各个亚型的表达、调控、生物学作用及与类风湿关节炎发病的关系进行阐述，为
类风湿关节炎的治疗提供新的思路。 |
| 英文摘要: |
| IL-17 is a pro-inflammatory factor which is involved in autoimmune diseases,such as rheumatoid arthritis and
systemic lupus erythematosus.It is mainly released by Th17 cell-a subtype of CD4+T cell. At present, the effect of IL-17 on the
patholagical process of rheumatoid arthritis has been widely paid attention attention. Anti-IL-17A antibodies, which are used for the
treatment of rheumatoid arthritis,psoriatic arthritis and other diseases, have been produced and entered clinical trials.But the role of IL-17
on pathological processes still needs to be further studied, and its effects also need to be further investigated. This article mainly reviews
the expression,regulation, biological functions of the IL-17 family and the relationship with rheumatoid arthritis to supply new ideas to
the treatment of rheumatiod arthritis. |
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