| 张石珠杨敬伟陈宪典姚本云吴永.急性肾损伤患者血清胱抑素-C及尿NGAL 水平的变化及其临床意义[J].现代生物医学进展英文版,2012,12(15):2943-2945. |
| 急性肾损伤患者血清胱抑素-C及尿NGAL 水平的变化及其临床意义 |
| The Serum Cystatin-C and Urinary NGAL Levels and its ClinicalSignificance of Acute Kidney Injury the Patients of Acute Kidney Injury |
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| DOI： |
| 中文关键词: 急性肾损伤 血清胱抑素-C 尿NGAL |
| 英文关键词: Acute kidney injury Serum cystatin-C Urinary NGAL |
| 基金项目: |
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| 中文摘要: |
| 目的：观察急性肾损伤(Acute kidney injury，AKI)患者血清胱抑素-C（Cystatin-C，CysC）及尿中性粒细胞明胶酶相关脂质运
载蛋白(Neutrophil gelatinase-associated lipocalin，NGAL)水平的变化及其临床意义。方法：选择60 例AKI 患者为实验组，50 例正
常健康人作为对照组，应用酶联免疫吸附法测定两组人群血清胱抑素-C 和尿NGAL 水平。结果：实验组与对照组相比血清胱抑
素-C 和尿NGAL 水平显著升高，差异有统计学意义（P<0.05）。实验组尿NGAL 检出率高于血清胱抑素-C、血肌酐，差异有统计
学意义（P<0.05）。结论：急性肾损伤患者血清胱抑素-C 和尿NGAL 均升高，其中尿NGAL 是反映AKI 较敏感的生物学标志物，
值得临床进一步研究。 |
| 英文摘要: |
| Objective: To observe the serum cystatin-C (CysC) and the urinary neutrophil gelatinase-associated lipocalin (NGAL)
level of the patients of the acute kidney injury (AKI) and to assess its clinical significance. Methods: We chose 60 patients of AKI as the
experimental group, and 50 healthy people as thecontrol group. The serum cystatin-C and urinary NGAL levels of two groups were
detected by enzyme-linked immunosorbent assay. Results: Compared with the control group, theserum cystatin-C and urinary NGAL
levels significantly increased, and the differences were statistically significant (P <0.05). The urinary NGAL detection rate was higher
than serum cystatin-C, serum creatinine of experimental group, and the difference was statistically significant (P <0.05). Conclusion:
Theserum cystatin-C and urinary NGAL of the patients of AKI were both increased,and the urinary NGAL was a more sensitive than the
serum cystatin-C, and it is worthy studying further. |
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