| 蔡民强1 杨利红1 周祥俊1 徐峰2 严淑贤2.急性心肌梗死患者血清cTnI、TNF-α、hs-CRP 水平变化及临床意义[J].现代生物医学进展英文版,2012,12(15):2940-2942. |
| 急性心肌梗死患者血清cTnI、TNF-α、hs-CRP 水平变化及临床意义 |
| Clinical Significance of Detecting Serum Levels of CTnI, TNF-α andHs-CRP in Patients with Acute Myocardial Infarction |
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| DOI： |
| 中文关键词: 急性心肌梗死 cTnI TNF-α hs-CRP |
| 英文关键词: Acute myocardial infarction CTnI TNF-α hs-CRP |
| 基金项目: |
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| 中文摘要: |
| 目的：研究急性心肌梗死患者血清心肌肌钙蛋白I（cTnI）、肿瘤坏死因子-α（TNF-α）及超敏C 反应蛋白（hs-CRP）水平变化
及临床意义。方法：对54 例急性心肌梗死患者血清cTnI、TNF-α、hs-CRP 水平进行检测，并与正常对照组的40 例健康受试者进行
比较分析。结果：急性心肌梗死组患者发病后6h、12h、24h、48h 及72h 血清中cTnI、TNF-α、hs-CRP 水平均显著高于正常对照组
（P<0.05）。其中hs-CRP 在患者发病12h 后达到高峰，而cTnI、TNF-α 均在发病后24h 达到高峰；hs-CRP 在患者发病早期的检出率
较高，发病后6h 患者血清hs-CRP 检出率与cTnI、TNF-α 的差异显著，具有统计学意义(P<0.05)。结论：动态监测急性心肌梗死患
者血清cTnI、TNF-α 及hs-CRP 水平对患者病情评估及治疗措施的选择具有重要的临床意义。 |
| 英文摘要: |
| Objective: To study the clinical significance of detecting the serum levels of cTnI, TNF-α and hs-CRP in patients with
acute myocardial infarction (AMI). Methods: The serum levels of cTnI, TNF-α and hs-CRP were detected in 54 patients with AMI, and
compared with those of 40 healthy subjects in the control group. Results: The serum level of cTnI, TNF-α and hs-CRP at 6h, 12h, 24h,
48h and 72h after desease in the AMI group were significantly higher than those in the control group(P<0.05). The serum level of hs-CRP
reached the peak at 12h, the serum levels of cTnI and TNF-α reached the peak at 24h; the detection rate of hs-CRP is significantly higher
than that of cTnI and TNF-α in the AMI group at 6h (P<0.05). Conclusion: Dynamic monitoring of the serum levels of cTnI, TNF-α and
hs-CRP play an important role in the disease assessment and treatment in patients with AMI. |
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