| 徐丽娟于壮△ 张永春陈丹杨堃侯宪鹏刘冰.TEM1mRNA 在非小细胞肺癌中的表达及临床意义*[J].现代生物医学进展英文版,2012,12(15):2904-2908. |
| TEM1mRNA 在非小细胞肺癌中的表达及临床意义* |
| Expression and Clinical Significance of TEM1 mRNAin Non-small Cell Lung Cancer* |
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| DOI： |
| 中文关键词: 非小细胞肺癌 TEM1 血管发生 实时荧光定量PCR |
| 英文关键词: Non-small cell lung cancer Tumor endothelial marker 1(TEM1) Angiogenesis RT-PCR |
| 基金项目:青岛市科技计划项目（06-2-2-5-nsh-1）；山东省科技发展计划项目（2010GWZ20260） |
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| 中文摘要: |
| 目的：揭示TEM1 其与非小细胞肺癌侵袭和转移的可能关系，为靶向治疗提供理想的药物作用靶点。方法：实时荧光定量
PCR 方法检测56 例非小细胞肺癌肿瘤组织及癌旁组织中TEM1 mRNA 表达水平，分析其在不同组中的表达差异。结果：TEM1
在56 例非小细胞肺癌组织中都有表达。TEM1 表达水平在肿瘤组织中比癌旁组织表达高，并且其表达水平与淋巴结转移及肿瘤
分期密切相关（P＜0.05），但与患者的病理类型，年龄及性别无关（P＞0.05）。结论：TEM1 表达水平与非小细胞肺癌分期密切相
关，表明其可能是一个参与非小细胞肺癌侵袭及转移有价值的分子标记物。TEM1 可能成为潜在的基因治疗靶点。 |
| 英文摘要: |
| Objective: To investigate the role of TEM1 as a therapeutic target in human endothelial cells. Methods: The mRNA
expression levels of TEM1 in tumor and corresponding paratumor tissue of NSCLC in 56 cases were detected by reverse quantitative
transcription polymerase chain reaction (QRT-PCR). And t tests were used to analyze statistical significances of their expression in
different groups. Results: Analysis of 56 arrayed gradeⅠ-Ⅲ NSCLC demonstrated TEM1 expression in all tissues. mRNA levels of
TEM1 were higher in tumor tissue than those in corresponding paratumor tissue. TEM1 expression was correlated with lymph node
metastasis and clinical stage (P＜0.05), but was independent of histological type, patient's age and gender (P＞0.05). Conclusion: The
expression level of TEM1 is correlated to clinical stage in NSCLC. It's probable a valuable molecular marker involved in NSCLC
invasion and metastasis. TEM1 expression profile in NSCLC supports efforts to therapeutically target this protein, might be potential
targets for gene therapy. |
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