| 孔祥云1,2 顾勇1,3 张永国1 沙素梅1 吴开春1△.Mc3 和Mc5 在溃疡性结肠炎癌变过程中的意义*[J].现代生物医学进展英文版,2012,12(15):2871-2875. |
| Mc3 和Mc5 在溃疡性结肠炎癌变过程中的意义* |
| The Significance of Mc3 and Mc5 in the Process of in Ulcerative ColitisCancerization* |
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| DOI： |
| 中文关键词: Mc3 Mc5 溃疡性结肠炎 上皮内瘤变 结直肠癌 |
| 英文关键词: Mc3 Mc5 Ulcerative colitis Intraepithelial neoplasia Colorectal cancer |
| 基金项目:卫生部行业科研专项项目（201002020） |
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| 中文摘要: |
| 目的：探讨Mc3 和Mc5 在溃疡性结肠炎- 上皮内瘤变- 癌变过程中的表达和临床意义。方法：利用免疫组化染色检测168
例溃疡性结肠炎（UC）、溃疡性结肠炎伴上皮内瘤变（UC+IN）、结直肠癌（CRC）中Mc3 和Mc5 的表达情况，分析Mc3 和Mc5 的
表达水平在溃疡性结肠炎- 上皮内瘤变- 癌变过程中变化趋势，探讨潜在的临床意义。结果：Mc3 和Mc5 在UC 的表达阳性率分
别为30%和29%，在UC+IN 的阳性率分别是48%和46%，在CRC 组的阳性率分别是91%和89%。统计分析发现，Mc3 和Mc5 在
溃疡性结肠炎、上皮内瘤变和结直肠癌的表达逐渐增加，差异具有统计学意义（P＜0.05）。结论：Mc3 和Mc5 在溃疡性结肠炎- 上
皮内瘤变- 癌变过程中表达逐渐增加，检测Mc3 及Mc5 的表达有助于判断癌变风险，且Mc3 和Mc5 具有较好的一致性。 |
| 英文摘要: |
| Objective: To investigate the expression and clinical significance of Mc3 and Mc5 during the development and
procession from ulcerative colitis (UC) to intraepithelial neoplasia (IN) to colorectal cancer (CRC). Methods: Immunohistochemical
staining was applied to evaluate the expression of Mc3 and Mc5 in the samples of ulcerative colitis (UC, n=66), ulcerative colitis with
intraepithelial neoplasia (UC+IN, n=52) and colorectal cancer (CRC, n=50). The expression changing tendencies were analyzed to
explore the potential clinical significance. Results: The positive expression rates of Mc3 and Mc5 expression were 30% and 29% in UC，
which were 48% and 46% in UC+IN, 91% and 89% in CRC. The expression level of Mc3 and Mc5 in UC, UC+IN and CRC increased
gradually and significantly (P＜0.05). Conclusion: The expression level of Mc3 and Mc5 increased gradually from UC to UC with IN to
CRC, which suggests testing the expression of Mc3 and Mc5 may help determine the risk of cancerization. |
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