| 付中伟徐玫杜可军戴鹏陈迎雷黄冠鹏蔡同建骆文静陈景元△.低压低氧暴露对大鼠空间记忆及海马谷氨酸受体表达的影响*[J].现代生物医学进展英文版,2012,12(15):2867-2870. |
| 低压低氧暴露对大鼠空间记忆及海马谷氨酸受体表达的影响* |
| Effect of Hypobaric Hypoxia to The Spatial Memory and GlutamateReceptor* |
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| DOI： |
| 中文关键词: 低压低氧 谷氨酸 空间记忆 GluR1 NMDA 兴奋性中毒 |
| 英文关键词: Hypobaric hypoxia Spatial memory Glutamate GluR1 NMDA Excitotoxicity |
| 基金项目:国家科技支撑计划（2009BA185B04） |
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| 中文摘要: |
| 目的：观察低压低氧暴露对成年大鼠空间记忆及谷氨酸递质系统受体（AMPA,NMDA）的影响。方法：SD 大鼠随机分成两
组，对照组和低氧组（n=10），经过5 天的Moriis 水迷宫训练，分别接受常压和低压低氧暴露7 天，再通过Morris 水迷宫观察暴露
后的空间记忆，western blot 检测GluR1，NMDA 受体表达情况。结果：水迷宫结果显示低压低氧暴露后，平均逃脱潜伏期增长，平
台搜索能力下降。Western blot 结果显示磷酸化的GLUR1 受体和NMDA 受体水平升高。结论：低压低氧暴露可诱导大鼠的空间
记忆损伤，其机制可能与谷氨酸递质系统紊乱造成的兴奋性中毒有关。 |
| 英文摘要: |
| Objective: To investigate the effects of explosure to hypobaric hypoxia environment on spatial memory in adult rats
and AMPA, NMDA receptors. Methods: Adult male SD rats were allocated randomized to the control and hypoxia groups. After five
days of Morris Water Maze test training, two groups respectively exposed to normal atmospheric pressure or hypobaric hypoxia for
7days. The spatial memory was observed by morris water maze test. Western blot was used to detect the expression of GluR1 and
NMDA. Result: In the Morris Water Maze test, the average escape latency increased and the ability to searching platform decreased
significantly in the hypoxia group. Western blot results showed that the levels of p- GluR1 and NMDA rose. Conclusion: Exposing to
hypobaric hypoxia leads to spatial memory damage in adult rats which may be related to the excitotoxicity resulted by glu transmitter
system disorder. |
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