| 陆燕1 刘沙2 刘的1 刘欣2 刘德全1 刘永海1.银杏内酯B 诱导大鼠骨髓间充质细胞分化为神经元样细胞的电生理研究[J].现代生物医学进展英文版,2012,12(15):2826-2828. |
| 银杏内酯B 诱导大鼠骨髓间充质细胞分化为神经元样细胞的电生理研究 |
| Electrophysiology Study on Differentiation of Rat Bone Marrow StromalStem Cells into Neurom-like Cells by Ginkgolide B |
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| DOI： |
| 中文关键词: 骨髓间充质细胞 银杏内酯B 全细胞膜片钳 神经元样细胞 |
| 英文关键词: Marrow stroma cell Ginkgolide B Whole cell patch clamp Neuron-like cell |
| 基金项目: |
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| 中文摘要: |
| 目的：研究银杏内酯B(GB)诱导大鼠骨髓间充质细胞(MSCs)分化为神经元样细胞的电生理特性。方法：应用膜片钳技术，采
用全细胞记录方式，对由GB 诱导的大鼠MSCs 进行诱导前后的电生理功能测定。结果：分化后的神经元样细胞较诱导前细胞的
膜特性有了显著改变(P<0.05)。结论：大鼠MSCs 经过GB 诱导能够向功能性神经元方向分化。 |
| 英文摘要: |
| Objective: To investigate the elctrophysiological properties of differentiation of rat bone marrow stroma cell (MSCs)
induced by Ginkgolide B (GB). Methods: Elctrophysiologica functions of rat MSCs before and after differentiating into neurons-like
cells were induced by GB. Results: The membrance properties changed a lot between differerntiated cell and undifferentiated neuron-like
cell (P<0.05). Conclusion: MSCs can differentiate into functional neurons if induced by GB. |
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