Article Summary
王健 邹仲敏 赵吉清.MiR-203 及其调控机制的研究进展[J].现代生物医学进展英文版,2012,12(14):2743-2747.
MiR-203 及其调控机制的研究进展
The Research Progress of MiR-203 and its Regulation Mechanisms
  
DOI:
中文关键词: MiR-203  调控  皮肤
英文关键词: MiR-203  Regulation  Skin
基金项目:国家自然科学基金面上项目(31171118)
Author NameAffiliation
WANG Jian, ZOU Zhong-min, ZHAO Ji-qing 第三军医大学军事预防医学院毒理学研究所 
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中文摘要:
      MicroRNA(miRNA)是一种长18-25 个碱基的单链非编码RNA,其广泛参与机体众多病理、生理过程。MiR-203 是一种上皮 组织特异性表达的miRNA。研究发现miR-203 在皮肤发育、皮肤相关疾病、上皮组织肿瘤等病理、生理过程中发挥重要调控作用。 一些疾病的研究还发现了miR-203 与表观遗传学机制的相互作用, 而miR-203 调控机制的研究集中在P63、SOCS-3 及相关的信 号通路等方面。
英文摘要:
      MicroRNAs (miRNA) are 18-25-nucleotide, single-stranded, non-coding RNAs that participate in many pathological and physiological processes of the body. MiR-203 is a miRNA specially expressed in epithelial tissue. Researches show that miR-203 plays an important role in skin development, skin-related diseases, epithelial tumors and other pathological and physiological processes. The interaction between miR-203 and epigenetic mechanisms is also discovered in the researches on some diseases, while the researches on the regulation mechanisms of miR-203 focus on P63, SOCS-3 and related signal pathways.
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