| 周伟彧 闫爽 刘思颖 朗宁 李志平 吉宗珊 张瑛琪 王玉晶.川芎嗪联合前列地尔治疗背景性糖尿病视网膜病变疗效的临床观察[J].现代生物医学进展英文版,2012,12(14):2713-2715. |
| 川芎嗪联合前列地尔治疗背景性糖尿病视网膜病变疗效的临床观察 |
| The Effectiveness of Ligustrazine Combined with AlprostadilTreatment on Background Diabetic Retinopathy |
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| DOI： |
| 中文关键词: 川芎嗪 前列地尔 背景性糖尿病视网膜病变 |
| 英文关键词: Ligustrazine Alprostadil Background diabetic retinopathy |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨川芎嗪(Ligustrazine)联合前列地尔(Alprostadil)治疗背景性糖尿病视网膜病变(Diabetic retinopathy，DR)的作用与
疗效。方法：收集近年我院糖尿病伴背景性DR 共73 例（112 只眼），分别按治疗中应用川芎嗪联合前列地尔或拜阿司匹林分为治
疗组与对照组，比较两组治疗前后患者眼底病变改善情况。结果：川芎嗪联合前列地尔的治疗组疗效比拜阿司匹林的对照组好；
眼底荧光检查表明，治疗组眼底病变改善明显好于对照组，差异显著(P<0.05)。结论：川芎嗪联合前列地尔对DR 有较好的疗效。 |
| 英文摘要: |
| Objective: Diabetic retinopathy (DR) is a blinding oculopathy which seriously influence human health and the leading
cause of blind in old patient beyond the age of 50 in China. This study aimed to observe the therapy effectiveness of Ligustrazine
combined with Alprostadil for background DR and discuss the mechanism. Methods：Select background DR patients (n=73). To treat the
retinopathy eyes (n=112), we set treatment group by using Ligustrazine combined with Alprostadil and control group by using Ligustrazaine
and Aspirin. Compare the eyeground pathological changes before and after treatment. Results：Treatment using Ligustrazine combined
with Alprostadil had a better performance after thyrapy compared before than Ligustrazaine and Aspirin. The overall efficacy was
68.97% in treatment group, while 38.89% in control group. Fluorescein fundus angiography showed that improvement for treatment was
obvious better than control, (P<0.05). Conclusion：Ligustrazine combined with Alprostadil therapy is effective for treat diabetic background
retinopathy. Conservative medical management plays an important role in DR. |
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