| 赵乃蕊 张弛 李华珠 杨晓春 周桂莲 王敏 熊璞 刘瑛.代谢正常肥胖个体发生非酒精性脂肪性肝病的相关性研究[J].现代生物医学进展英文版,2012,12(14):2691-2694. |
| 代谢正常肥胖个体发生非酒精性脂肪性肝病的相关性研究 |
| Study on the Relation between Metabolically Healthy Obeseand Nonalcoholic Fatty Liver Disease |
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| DOI： |
| 中文关键词: 肥胖 代谢正常肥胖 非酒精性脂肪性肝病 代谢综合征 |
| 英文关键词: Obese Metabolically healthy obese (MHO) Nonalcoholic fatty liver disease(NAFLD) Metabolic syndrome(MS) |
| 基金项目:湖南省科技计划项目（2011SK3160） |
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| 中文摘要: |
| 目的：探讨代谢正常肥胖（Metabolically healthy obese，MHO）个体与非酒精性脂肪性肝病（Nonalcoholic fatty liver disease，
NAFLD）发生的相关性。方法：选择2006 年4 月~2010 年1 月来湖南省人民医院体检中心体检人群共4076 例，排除过量饮酒
者、乙肝标志物阳性者及相关资料不全者共2830 例纳入本研究。其中1367 例在1~3 年后再次体检。记录受检者身高、体重、血
压、血脂、空腹血糖、腹部B 超结果。NAFLD 采用2010 年中华医学会肝病学分会诊断标准中影像学诊断定义，行腹部B 超检查进
行诊断。结果：1. 我院体检人群中MHO 合并NAFLD 者占51.34%，明显高于正常对照组（P=0.000），MHO 组发生NAFLD 的
OR 值为19.967（95%CI，12.646-31.533；P=0.000）。2.随访1~3 年后，MHO 中NAFLD 发病率高于正常对照组（44.44% vs 7.02%，
OR=10.600，95%CI，4.873-23.058；P=0.000）。结论：MHO 个体合并NAFLD 比例较正常对照者升高，MHO 个体增加NAFLD 患病
风险。 |
| 英文摘要: |
| Objective: To investigate the relation between metabolically healthy obese and nonalcoholic fatty liver disease.
Methods: 4076 subjects were examined for routine health in People's Hospital of Hunan Province from April 2006 to January 2010, 2830
individual were enrolled excluding those with hepatitis B viruses, excessive alcohol consumption and missing data. 1367 individual were
followed up in 3 years. Data were collected of those individuals on body height, body weight, blood pressure, lipid profile and fast blood
glucose. Diagnosis of NAFLD was made by B-ultrasound based on the criteria of Chinese Society of Hepatology of imaging diagnosis of
NAFLD in 2010. Results: 1. The percentage of NAFLD in individuals with MHO was 51.34% in subjects with healthy examination in
People's Hospital of Hunan Province, which was significantly higher than that in normal controls (P=0.000). The presence of MHO was
associated with an increased risk of NAFLD (OR=19.967; 95%CI, 12.646-31.533, P=0.000). 2. Following up for 1 to 3 years, we found
that the incidence of NAFLD in patients with MHO was significantly higher than that in normal controls (44.44% vs 7.02%, OR=10.600,
95% CI, 4.873-23.058, P=0.000). Conclusions: The percentage of NAFLD in individuals with MHO was significantly higher than that in
normal controls, MHO may increase the risk of NAFLD. |
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