| 陈立武 曾志刚 林东 陈志钦 桂翔.番茄红素联合CIK 治疗的抗肿瘤作用的实验研究[J].现代生物医学进展英文版,2012,12(14):2638-2641. |
| 番茄红素联合CIK 治疗的抗肿瘤作用的实验研究 |
| Experimental Studies on the Anti-Tumor Effects of Combined Treatmentwith Lycopene and Cytokine-Induced Killer |
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| DOI： |
| 中文关键词: 番茄红素 细胞因子诱导的杀伤细胞 荷瘤小鼠 |
| 英文关键词: Lycopene Cytokine-induced killer Tumor-bearing mice |
| 基金项目:中美多中心合作课题《益气养阴中药增强消化道肿瘤患者术后免疫功能的研究》（2008DFA32200） |
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| 中文摘要: |
| 目的：探讨番茄红素联合细胞因子诱导的杀伤细胞(CIK)治疗的抗肿瘤作用及相应机制。方法：建立荷B16-F10 黑色素瘤小
鼠模型，观察联合治疗对肿瘤体积、宿主生存时间、淋巴细胞增殖活力及淋巴细胞杀伤能力的影响。结果：CIK 及番茄红素治疗均
可以抑制肿瘤的生长，延长荷瘤鼠的生存时间。与CIK 治疗组相比较，中高剂量的番茄红素联合CIK 治疗可以显著增强抗肿瘤
疗效，延长荷瘤鼠的生存时间，并且可以通过刺激荷瘤鼠淋巴细胞增殖、增强淋巴细胞对肿瘤的杀伤能力提高CIK 治疗的抗肿瘤
疗效。结论：番茄红素能够通过提高宿主免疫水平而显著增强CIK 治疗的抗肿瘤效果。 |
| 英文摘要: |
| Objective: The present study was aimed to assess the anti-tumor effects of combined treatment with lycopene and
cytokine-induced killer (CIK) and to investigate the possible mechanism involved. Methods: B16-F10 melanoma tumor-bearing mice
model was established and changes in tumor volume, survival of recipients, lymphocyte proliferation and cytotoxicity after combined
treatment were analyzed. Results: Both CIK and lycopene treatment can inhibited tumor growth and prolonged the survival of recipients.
Compared with CIK treatment, combined treatment with lycopene and CIK could significantly enhance the anti-tumor effects, prolong
the survival of recipients, promote the proliferation of lymphocyte subsets and increase the cytotoxicity of lymphocyte. Conclusion:
Lycopene treatment could increase the levels of host immunity and thus promote the anti-tumor effects of CIK. |
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