| 连帅彬戴宪华△.衰老癌症基因稳定性与干细胞肿瘤特性[J].现代生物医学进展英文版,2012,12(12):2391-2396. |
| 衰老癌症基因稳定性与干细胞肿瘤特性 |
| Aging, Cancer, Genome Stability and Tumorigenicity of Stem Cells |
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| DOI： |
| 中文关键词: 衰老 癌症 基因稳定性 胚胎干细胞 多功能干细胞 |
| 英文关键词: Aging Cancers Genome Stability HESCs HiPSCs |
| 基金项目:国家自然科学基金（Grant 61174163） |
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| 中文摘要: |
| 衰老和癌症一直是生物医学研究的热点，诱发衰老和癌症的原因很多，为了攻克衰老与癌症的难题，科学家们对多功能干
细胞进行大量的研究，但是发现多功能干细胞也具有致瘤特性。本文从DNA 稳定性的角度出发，综合最新的研究成果，对当前生
物医学领域的研究热点进行了系统的综述，主要包括DNA 损伤与修复机制，造成衰老的因素，癌症的特性，以及胚胎干细胞与多
功能干细胞的肿瘤特性等。 |
| 英文摘要: |
| Aging and cancer are always the hot research points of bioinformatics and medical for many years, which can be
induced by a mount of reasons. In order to cope with difficulties, scientists have done many researches on Pluripotent Stem Cells (PSC) .
However, the PSCs also have tumorigenicities. In this paper, from the perspective of DNA stability, we review the hot research points in
biomedicals including: the types of DNA damage and repair, the reasons for aging, the characteristics of cancers, the tumorigenicities of
human embryonic stem cells (HESCs) and human induced pluripotent stem cells (HiPSCs). |
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