| 杨春周华杜煦谢骞张银莉.多种血清肿瘤标志物联合检测对肺癌诊断的临床意义分析[J].现代生物医学进展英文版,2012,12(12):2337-2339. |
| 多种血清肿瘤标志物联合检测对肺癌诊断的临床意义分析 |
| Clinical Significance of Variety of Serum Tumor Markers in Detectionof Lung Cancer |
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| DOI： |
| 中文关键词: 肿瘤标记物 肺癌 敏感度 |
| 英文关键词: Tumor markers Lung cancer Sensitivity |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨CA125、CYFRA21- 1、CEA、NSE、AFP 联合检测对肺癌的诊、诊断的敏感度以及特异性。方法：对我院收治的确诊
为肺癌的患者选取120 例作为A 组，同期选择肺部良性病变患者61 例作为B 组，以及50 例健康体检患者作为C 组，将三组研
究对象分别进行CA125、CYFRA21- 1、CEA、NSE、AFP 的检测。结果：A 组患者CA125、CYFRA21- 1、CEA、NSE、AFP 的血清中含
量明显高于B 组以及C 组（P＜0.05）；五种标记物联合检测的敏感度明显高于单一标志物的敏感度（P＜0.05），但其特异性有明显
的降低（P＜0.05）。结论：采用CA125、CYFRA21- 1、CEA、NSE、AFP 联合检测，对肺癌的早期诊断以及治疗预后有较好的指导作
用。 |
| 英文摘要: |
| Objective: To explore the combined detection with CA125, CYFRA21-1, CEA, NSE, AFP for lung cancer diagnosis
and their diagnostic sensitivity and specificity. Methods: 120 cases of patients diagnosed with lung cancer in our hospital were selected as
the group A, and 61 cases of benign lung disease patients at the same period were selected as group B, and 50 healthy subjects as group
C. Three groups of subjects were received respectively CA125, CYFRA21-1, CEA, NSE, AFP testing. Results: Patients in group A had
significantly higher CA125, CYFRA21-1, CEA, NSE and AFP serum levels than patients in group B and group C (P <0.05). Combination
detection with five kinds of markers showed a significantly higher sensitivity than single marker detection (P<0.05), but a remarkable
lower specificity (P<0.05). Conclusion: Combination detection with CA125, CYFRA21-1, CEA, NSE, and AFP give a better guidance on
early diagnosis of lung cancer and the treatment and prognosis. |
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