| 徐纯王景杰△.HCN 通道在生物胃肠道起搏机制中作用研究现状[J].现代生物医学进展英文版,2012,12(10):1992-1994. |
| HCN 通道在生物胃肠道起搏机制中作用研究现状 |
| Research on the Function of HCN Channels in Pace-making Mechanisms ofBiological Gastrointestinal Tract |
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| DOI： |
| 中文关键词: 超极化激活环核苷酸门控阳离子通道 胃肠道 起搏电流 ICC |
| 英文关键词: Hyperpolarization-activated cyclic nucleotide-gated channels Gastrointestinal tract Pacemaker current Interstitial cells
of Cajal |
| 基金项目: |
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| 中文摘要: |
| HCN 通道（hyperpolarization-activated cyclic nucleotide-gated channels）是一种超极化激活的，钠、钾、钙离子混合通透的，直接
受cAMP 调控的离子通道，在人体内的分布具有一定的组织和细胞特异性，其不仅与神经系统疾病联系紧密，与胃肠道动力障碍
疾病也存在一定联系。对HCN 通道生理功能、在胃肠起搏电流形成中作用及与疾病的关系的深入了解，必将对今后的研究以及
临床治疗有实际意义 |
| 英文摘要: |
| Hyperpolarization-activated cyclic nucleotide-gated channels are hyperpolarization-activated ion channels which can
be regulated directly by cAMP and penetrated by Na+, Ka+ and Ca2+. The distribution of the HCN channels in human body shows certain
specificities in tissues and cells. They are not only in close relevance with nerve system diseases, but also in connection with
gastrointestinal motility diseases. A deepgoing understanding of the physiological functions of HCN channels、the role in the formation of
pacemaker current and relation with diseases will undoubtedly have practical significance for the researches and clinical treatments in the
future. |
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