| 宋旺胜曹云△ 马春辉.骨性关节炎生物学标志物研究进展[J].现代生物医学进展英文版,2012,12(10):1969-1971. |
| 骨性关节炎生物学标志物研究进展 |
| Progress of Stdudy on Biomarkers of Osteoarthritis |
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| DOI： |
| 中文关键词: 骨性关节炎 生物学标志物 研究进展 |
| 英文关键词: Osteoarthritis Biomarker Progress |
| 基金项目: |
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| 中文摘要: |
| 骨性关节炎（oseteoarthritis,OA）是一种随着年龄增长发病率明显升高的退行性变，常累及脊柱、髋、膝等人体负重关节，以关
节缓慢发展的疼痛、肿胀，伴功能障碍为临床表现，主要有滑膜增生、软骨破坏、软骨下骨骨化及骨赘形成等一系列病理表现。OA
对人类的健康和生活质量影响很大，随着老龄化社会的到来，本病的发病率日趋升高，其研究已成为医学领域中的重要课题。目
前，OA 的早期诊断、病变监测和有效防治仍是骨科领域亟待解决的疑难问题。随着分子生物学的发展和研究手段的提高,许多研
究者都在试图寻找用于临床评价OA 的生物学标志物。本文将就OA 研究中所使用的主要标志物进行综述，为深入研究OA 提供
方便。 |
| 英文摘要: |
| Osteoarthritis is a progressive degeneration whose incidence is increased with age, often involving the vertebral
column ,hip,and knee joints,characterized by chronic pains, swelling and disfunction clinically and synovial proliferation,cartilage
distruction,subchondral bone ossification, osteophyte formed pathologically. OA has great effect on people's health and life quality.
Along with the arrival of aging society, OA has become an important subject in medical area. Resently, early diagnosis,monitoring and
prevention of OA is still a burning question in orthopedic field. With the development of molecular biology and research method,many
scholars are trying to find some useful biomarkers for clinic evaluation.This review will provide convenience for further reseach of OA. |
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