| 薛媛1 杨传民1△ 董蒨1 姜忠1 段于河1 周全2.CXCR4 及VEGF 在肾母细胞瘤中的表达及其意义[J].现代生物医学进展英文版,2012,12(10):1949-1951. |
| CXCR4 及VEGF 在肾母细胞瘤中的表达及其意义 |
| Expression and Significance of CXCR4 and VEGF in Nephroblastoma |
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| DOI： |
| 中文关键词: 肾母细胞瘤 趋化因子受体4 血管内皮生长因子 免疫组织化学 |
| 英文关键词: Nephroblastoma CXCR4 VEGF Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：检测趋化因子受体4（CXCR4）及血管内皮生长因子（VEGF）在肾母细胞瘤中的表达,探讨其在肾母细胞瘤的发生、发
展、浸润和转移中的作用。方法：选择临床及病理资料齐全的存档肾母细胞瘤标本30 例,另取正常肾脏标本10 例作对照。采用免
疫组化(SABC) 方法检测CXCR4 及VEGF 的表达。结果：CXCR4 在肾母细胞瘤组织中高表达(66.67%)，在正常肾脏组织中低表
达（30.0%），两者相比有统计学意义（P<0.05）, VEGF 在肾母细胞瘤组织中高表达(73.33%)，在正常肾脏组织中低表达（20.0%），两
者相比同样有统计学意义(P<0.05)，肾母细胞瘤组织中CXCR4 与VEGF 的表达两者之间呈正相关性（r＝0.392，P<0.05）。结论：
肾母细胞瘤组织中CXCR4 和VEGF 均高表达。CXCR4 及VEGF 可能成为预测肾母细胞瘤浸润转移的重要指标。 |
| 英文摘要: |
| Objective: To detect the expression and significance of CXCR4, VEGF and their correlations in Nephroblastoma, so as
to investigate their effect on metastasis and development of the tumor. Methods: SABC immunohistochemistry was used to detect the
expression of CXCR4 and VEGF, in 30 samples of Nephroblastoma tissue selected from paraffin wax-embodied specimens with
complete clinicopathological data, and other 10 cases of normal kidney tissue. Results: The expression of CXCR4 in normal kidney tissue
was lower (30.0%) than that in Nephroblastoma (66.67%), and the difference was significant （X2=4.126, P<0.05）.The expression of
VEGF in Nephroblastoma was higher (73.33%) than that in normal kidney tissue (20.0%) and the difference was also significant(X2=8.
889, P<0.05). The expression of CXCR4 was significantly positively correlated with the expression of VEGF in Nephroblastoma (r =0.
392, P < 0.05). Conclusions: CXCR4 and VEGF had highly expression in Nephroblastoma. CXCR4 and VEGF may be served as the
markers in the estimation of metastasis and dissemination of Nephroblastoma. |
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