| 罗旦喻红波黎健刘阳唐志强.粪乳铁蛋白和C 反应蛋白对溃疡性结肠炎的评价[J].现代生物医学进展英文版,2012,12(10):1946-1948. |
| 粪乳铁蛋白和C 反应蛋白对溃疡性结肠炎的评价 |
| Fecal Lactoferrin and Serum C-reactive Protein for the Assessment inUlcerative Colitis |
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| DOI： |
| 中文关键词: 溃疡性结肠炎 粪乳铁蛋白 C 反应蛋白 |
| 英文关键词: Ulcerative colitis C-reactive protein Lactoferrin |
| 基金项目: |
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| 中文摘要: |
| 目的：研究粪乳铁蛋白（1actoferrin，LF）和C 反应蛋白（C-reactive protein, CRP）对溃疡性结肠炎的严重程度、活动性和对治
疗反应的评价作用。方法：选取我院2009-2010 年43 例特发性溃疡性结肠炎患者，同时进行对照平行研究。对患者进行临床评
估、内镜和病理检查，了解疾病活动性、严重程度，并检测LF、CRP 在治疗前后的水平。结果：与对照组相比较，病例组生物学标志
都升高（P = 0.000)，特发性溃疡性结肠炎严重组粪LF 和CRP 更高，治疗后，生物学指标下降到与Mayo 分数齐平,ROC 曲线下面
积分别为0.953 和0.721，其灵敏度和特异性分别为：LF(90.7%,100%)和CRP (44.2%,100%)。结论：在对特发性溃疡性结肠炎的活
动性、严重程度和对治疗反应的评价中，粪LF 和CRP 是非常有用的生物学指标。 |
| 英文摘要: |
| Objective: To examine the role of serum C-reactive protein (CRP), and fecal lactoferrin (LF) in assessing ulcerative
colitis (UC) severity, activity and response to therapy. Methods: 43 consecutive patients with UC attending our hospital from 2009 to
2010 were studied. An equal number of healthy age-matched controls were studied for biomarker levels. All underwent clinical,
endoscopic and histological assessment for disease activity, extent, severity and estimation of CRP and LF levels at baseline and follow
up. Results: The both biomarkers were elevated more often in the cases than in the controls (all P = 0.000). Cases with severe UC had
higher CRP and LF titers than those without severe IUC. After treatment, a significant fall in biomarker levels paralleled the reduction in
Mayo's scores. The areas under the curve for LF and CRP were 0.953 and 0.721, respectively. The sensitivity and specificity of markers
were: LF (90.7%,100%), and CRP (44.2%,100%). Conclusion: The both biomarkers are useful in assessing disease activity, severity and
response to therapy in patients with UC. |
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