| 甄云飞曲海霞王青△.食管腺癌、Barrett 食管活检粘膜中TGF-β1 的表达[J].现代生物医学进展英文版,2012,12(10):1941-1942. |
| 食管腺癌、Barrett 食管活检粘膜中TGF-β1 的表达 |
| Expression of TGF-β1 of the Esophageal Mucosa of Patientswith Esophageal Adenocarcinoma or Barrett Esophagus |
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| DOI： |
| 中文关键词: 食管腺癌 Barrett 食管 转化生长因子β1 免疫组织化学 |
| 英文关键词: Esophageal adenocarcinoma Barrett esophagus Transforming growth factor-beta l Immuno-histochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：研究食管腺癌、Barret 食管（Barrett esophagus, BE）和正常食管粘膜中转化生长因子β1 (transforming growth factor-beta
l, TGF-β1)的表达。方法：采用免疫组化方法检测35 例食管腺癌患者、40 例BE 患者及30 例健康对照组食管组织中TGF-β1 的表
达水平。结果：未在健康对照组食管粘膜中发现TGF-β1 的表达，食管腺癌组TGF-β1 的表达水平>BE 组> 健康对照组（P<0.
05）。食管腺癌组中，TGF-β1 在中- 高分化腺癌及低分化腺癌患者食管粘膜中的表达无明显差异（Z=1.07, P>0.05）。结论：食管腺
癌、BE 食管粘膜中TGF-β1 表达水平升高，在食管腺癌中的表达与细胞分化程度无关。 |
| 英文摘要: |
| Objective: To investigate the expression of TGF-β1 of the esophageal mucosa of patients with esophageal
adenocarcinoma or Barrett esophagus (BE). Methods: Thirty five cases in esophageal adenocarcinoma, forty cases in BE, thirty cases in
the control group were enrolled the test. The expression of TGF-β1 of all specimens was detected by immuno-histochemistry. Results:
There was no expression of TGF-β1 in the normal esophageal mucosa. The expression of TGF-β1 in the esophageal adenocarcinoma
group> BE group > control goup （P<0.05）. In the esophageal adenocarcinoma group, no significant difference was found in the
expression level of TGF-β1 in moderately-differentiated or well-differentiated specimens with the poorly-differentiated ones（Z=1.07，
P>0.05）. Conclusions: There was a high expression of TGF-β1 in the esophageal mucosa of patients with esophageal adenocarcinoma or
Barrett esophagus (BE). There was no association between the expression of TGF-β1 and the degree of cellular differentiation in the
esophageal mucosa of patients with esophageal adenocarcinoma. |
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