| 强少盈1 张菊2 张华伟3 王鹏博3 刘文超1.血清多肿瘤标志物蛋白芯片检测在乳腺癌诊断中的价值[J].现代生物医学进展英文版,2012,12(10):1923-1926. |
| 血清多肿瘤标志物蛋白芯片检测在乳腺癌诊断中的价值 |
| Application and the Reseach Progress of Multiple Sarum Tumor MarkerProtein Chip Detection for Breast Cancer |
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| DOI： |
| 中文关键词: 肿瘤标志物 乳腺癌 诊断 |
| 英文关键词: Tumor marker Breast cancer Diagnosis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨血清多肿瘤标志物蛋白芯片检测系统在乳腺癌诊断中的临床价值。方法：临床确诊的乳腺癌患者307 例为乳腺癌
组，非乳腺癌的其他恶性肿瘤患者495 例为对照组。应用多肿瘤标志物蛋白芯片检测系统检测12 种肿瘤标志物水平，评价血清
肿瘤标志物的在乳腺癌组与对照组之间的差异。结果：CA153，CEA，Free-PSA 这三项指标为诊断乳腺癌的独立相关因素(P<0.05),
比较三项指标ROC 曲线下面积可见，CA153 对于鉴别乳腺癌准确性更高，其敏感性、特异性分别为78.92 和56.14，女性乳腺癌患
者Free-PSA 可见明显升高，对乳腺癌有特殊提示意义，手术前后标志物CA199、CA242、Ferrin、CA125 水平差异有统计学意义。结
论：在临床常用的肿瘤标记物中，CA153，CEA，Free_PSA 水平的升高与乳腺癌发生独立相关，其中CA153 具有更高的诊断准确
性，Free_PSA 水平升高对乳腺癌的诊断有特别提示意义。 |
| 英文摘要: |
| Objective: To investigate the diagnostic value of multi-tumor markers protein biochip detective system in the diagnosis
of breast cancer. Methods: Three hundred and seven patients with breast cancer (breast cancer group)and four hundred and ninty five
patients with other cancer (control group)were studied. Serum CEA,AFP,CA125,CA15-3,CA19-9,CA242, Ferr and others were measured
with the multi-tumor markers protein biochip detective system. The levels of the markers above were compared between the breast cancer
group and the control group. Those with a P value of <0.1 were entered into a multivariate analysis. Then the receivers operating curve
(ROC) was performed The diagnostic value of each markers was compared using the area under the curve. Results: The levels of CA153,
CEA,Free-PSA in breast cancer group were higher than in control group (P<0．01)．From the ROC Curve ,CA153 is the most sensitive
tumor marker in breast cancer. There is a distinct difference in the level of CA199,CA242,Ferrin,CA125 between patients have surgery
and those who have not had surgery. Conclusion: The rise of CA153,CEA,Free-PSA have an independent relation with breast cancer, and
CA153 has higher diagnosis accuracy. The level of Free_PSA has a special significance in the diagnosis of breast cancer. |
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