| 岳英杰费昶△ 张健.脑膜瘤WHO 分级及其基因学研究进展[J].现代生物医学进展英文版,2012,12(9):1788-1790. |
| 脑膜瘤WHO 分级及其基因学研究进展 |
| This Meningioma Classification and Genetics Research Progressof the WHO |
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| DOI： |
| 中文关键词: 脑膜瘤 WHO 分级 基因学 研究进展 |
| 英文关键词: Meningiomas The WHO classification Genetics Research progress |
| 基金项目:山东省科技发展项目（2008GG30002057） |
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| 中文摘要: |
| 脑膜瘤是颅内第二大常见肿瘤。WHO 根据组织学及肿瘤生物学将脑膜瘤分为3 级。目前，随着脑膜瘤研究的深入及肿瘤分
子生物学的发展，脑膜瘤在基因学方面的研究越来越受到重视。其中包括原癌基因的激活和抑癌基因的失活。现阶段，比较公认
的与肿瘤包括脑膜瘤形成有关的原癌基因主要有c-myc 基因、bcl-2 基因、Survivin 基因及mdm2 基因等，抑癌基因主要有p53 基
因、p73 基因、NF-2 基因及p16 基因等。这些基因通过不同的机制发生不同的改变最终参与了不同级别脑膜瘤的发生和发展。现
就其研究进展做一综述。 |
| 英文摘要: |
| Meningiomas is the second most common cancer in the central system. The meningioma will be divided into three
levels according to the WHO histology and tumour biology. Now, along with the meningioma's development of research and the tumor's
development of molecular biology, this meningioma in the genetic research more and more attention to. Including protocarcinogenic gene
activation and tumor-suppressor gene inactivation. At present, it is recognized and tumor including meningioma form of cancer genes related
the main c-myc genes, BCL-2 genes, Survivin mdm2 gene and gene, tumor suppressor genes p53 genes, p73 main gene, NF-2 gene
and p16 genes, etc. These genes through the different mechanism of different change happen eventually involved in the different levels of
meningiomas occurrence and development. The research progress is reviewed. |
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