| 谢菡1 葛卫红1△ 于峰2△.超声介导镇痛药物透皮吸收研究进展[J].现代生物医学进展英文版,2012,12(9):1760-1762. |
| 超声介导镇痛药物透皮吸收研究进展 |
| The new study of Ultrasound-Mediated Transdermal Analgesic Drugs |
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| DOI： |
| 中文关键词: 超声 增透 镇痛药物 临床前试验 临床试验 |
| 英文关键词: Ultrasound-mediated Analgesic drugs Pre-clinical trials Clinical trial |
| 基金项目: |
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| 中文摘要: |
| 现阶段，临床中常用的镇痛药物多采用口服或注射给药的方式，具全身不良反应多，患者依从性差等缺点，透皮给药作为一
种非侵入性给药方式，相对于这些有很多显著的优势，如使用方便，患者痛苦少等。但是，如何克服皮肤的低渗透性一直是该种给
药方式发展的瓶颈。近年来，使用超声能量增强镇痛药物在皮肤上的的渗透性成为新的研究热点，各项研究发现，低频超声对药
物的增透效果尤为显著。本文通过检索各国文献，对超声介导镇痛药物透皮吸收的原理，临床前试验和临床试验进行综述。 |
| 英文摘要: |
| Resently, the most of analgesic drugs used in oral or injection have lots of disadvantagement such as adverse reactions,
poor patient compliance and so on. Transdermal drug delivery, a non-invasive drug delivery, has many significant advantages compared
to the the traditional drug delivery. However, how to overcome the low permeability of the skin is the bottleneck of ultrasound-mediated
transdermal. In recent years, enhance analgesic drugs permeability of the skin by ultrasonic energy become a new hotspot. Many
researches found that the drug effect of low-frequency ultrasound to increase the permeability is particularly significant. This literature
reviews the principles, pre-clinical trials and clinical trial of ultrasound-mediated transdermal analgesic. |
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