| 孙晓莉1,2 高美华1△ 王在秋3 杨建华2 于丽梅2.HPV-DNA 与TCT 联合检测在宫颈癌诊断中的应用[J].现代生物医学进展英文版,2012,12(9):1745-1747. |
| HPV-DNA 与TCT 联合检测在宫颈癌诊断中的应用 |
| Application of HPV-DNA Detecting with TCT test in CervicalCarcinoma Diagnosis |
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| DOI： |
| 中文关键词: 人乳头瘤病毒（HPV） 液基细胞学检查（TCT） 宫颈癌 |
| 英文关键词: Human pallomavirus(HPV) Liquid-based cytological test(TCT) Cervical carcinoma |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨高危型人乳头状瘤病毒（HPV）DNA 检测与液基细胞学检查（TCT）在子宫颈病变诊断中的应用价值。方法：对
600 例患者分别做HPV-DNA 和TCT 检测，对其中一项或两项异常者做阴道镜病理活检，对病理结果阳性患者进行HPV-DNA
和TCT 检测结果分析。结果：其中一项或两项异常者150 例，HPV-DNA 检测阳性者（H 组）为115 例，其中病理结果阳性为39
例，符合率为33.9%；TCT 检测阳性者（T 组）为76 例，其中病理结果阳性为40 例，符合率为33.9%；两项均为阳性者（H+T 组）是
56 例，其中病理结果阳性为51 例，符合率为91.1%。H 组与H+T 组比较x2=13.95，P<0.01；T 组与H+T 组比较x2=4.00，P<0.05，结
果有显著差异。结论：HPV-DNA 及TCT 联合起来进行检测可以提高宫颈癌及癌前病变的筛查及早期诊断的检出率。 |
| 英文摘要: |
| Objective: To study the value of HPV-DNA deteceting and TCT in cervical diseases dignosis. Methods: 600 cases of
female received HPV-DNA and TCT detection. The positive result of the detections with one or two had colposcopic biopsy and pathological
examination. Results: Among 150 cases with one or two detect positive, there were 115 positive cases for HPV-DNA (H Group),
with 39 positive of pathological exam,coincidence rate is 33.9%;76 positive cases for TCT test (T Grouop),with 40 positive of pathological
exam,coincidence rate is 52.6%;there were 56 cases for both,with 51 positive of pathological exam coincidence rate is 91.1%.Compared
with H Group and H+T Group,x2=13.95,P<0.01; Compared with T Group and H+T Group, x2=4.00,P<0.05.there were significant differences
in the result. Conclusions: The positive rate can be raised by combining HPV-DNA and TCT detects in screening and early diagnosis
of cervical carcinoma and cervical precancerous lesions. |
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