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目的：分析检测血清、胸水中白细胞介素6（IL-6）、白细胞介素8（IL-8）水平对良恶性胸水的鉴别诊断价值。方法：采用酶联免疫吸附试验（ELISA）检测32 例良性胸水患者和40 例恶性胸水患者血清及胸水中IL-6、IL-8 水平，以及30 例健康体检者血清中 IL-6、IL-8 水平。结果：良性胸水组及恶性胸水组血清IL-6、IL-8 水平均显著高于正常对照组，差异具有统计学意义（P<0.05）；与恶性胸水组比较，良性胸水组胸水及血清中IL-6、IL-8 水平升高更为显著（P<0.05），良性胸水组IL-6、IL-8 的胸水/ 血清比值也显著高于恶性胸水组，差异具有统计学意义（P<0.05）。结论：胸水及血清中IL-6、IL-8 的检测对良、恶性胸水患者具有鉴别诊断意义。

英文摘要:

Objective: To explore the differential diagnosis value of determination of IL-6, IL-8 in serum and pleural effusion between benign and malignant hydrothora. Methods: The levels of IL-6, IL-8 in serum and pleural effusion of 32 cases with benign hydrothorax, 40 cases with malignant hydrothora were detected, and the levels of IL-6, IL-8 in serum of 30 healthy subjects were detected by ELISA. Results: The levels of IL-6, IL-8 in serum were significantly increased in cases with benign or malignant hydrothora in comparison with those of control group, the difference was statistically significant (P<0.05). There were statistically significant differences of the levels and the pleural effusion/serum ratio of IL-6, IL-8 in serum and pleural effusion between benign and malignant hydrothora (P>0.05). Conclusion: The levels of IL-6, IL-8 in serum and pleural effusion may be used as an marker in the differential diagnosis of benign and malignant hydrothora.

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