| 张静慈春增△ 王晓东刘润荣刘占诺.系统性红斑狼疮患者血清中IL-17 的检测及临床意义[J].现代生物医学进展英文版,2012,12(9):1704-1706. |
| 系统性红斑狼疮患者血清中IL-17 的检测及临床意义 |
| The Detection and Clinical Significance of Serum IL-17 in Patientswith Systemic Lupus Erythematosus |
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| DOI： |
| 中文关键词: 系统性红斑狼疮 白介素17 系统性红斑狼疮疾病活动性指数 酶联免疫吸附 |
| 英文关键词: Systemic lupus erythematosus Interleukin-17 SLEDAI Enzyme linked immunosorbent assay |
| 基金项目: |
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| 中文摘要: |
| 目的：通过检测系统性红斑狼疮（SLE）患者外周血中IL-17 的水平，探讨其临床意义。方法：用酶联免疫吸附法（enzyme
linked immunosorbent assay, ELISA）检测61 例SLE 患者及30 例健康人血清IL-17 水平,并收集整理SLE 患者的临床资料及实验
室数据,分析其与临床的关系。结果：活动期SLE 患者血清IL-17 水平明显高于正常对照组（P<0.01），与SLE 非活动组相比，差异
亦有统计学意义（P<0.01）。但SLE 非活动组与正常对照组间无统计学意义。结论：IL-17 水平在活动期SLE 患者血清中表达明显
增高，且与SLEDAI 评分呈正相关,提示IL-17 可能参与了SLE 疾病的病理过程，可能与疾病活动的关系密切。 |
| 英文摘要: |
| Objective: To analyze the levels of interleukin 17 （IL-17）in the peripheral blood of patients with SLE,and to investigate
the clinical significance. Methods: IL-17 levels were assessed in 61 SLE patients and 30 normal controls by enzyme-linked immunosorbent
assay（ELISA）. And the clinical and laboratory data of the patients were collected.To explor the relationship between IL-17
and clinical of SLE patients. Results: The plasma concentration of IL-17 was significantly elevated in SLE patients as compaired to the
normal control group （P<0.01）. Compared with patients wi th inactive SLE, the levels of IL-17 had the statistic differences, and there
showed no statistic differences between patients with inactive SLE and normal controls. Conclusion: IL-17 in the sera of untreated SLE
patients is significantly higher, and the levels of them are positively correlated with SLEDAI scores. The results suggest that IL-17 may
play an important role in the pathogenesis of SLE, especially in active SLE. |
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