| 李强黄波△ 何莲刘骞孙媛商冠宁.胃癌中CD44v6 表达及与微血管密度和生物学行为的关系[J].现代生物医学进展英文版,2012,12(9):1686-1689. |
| 胃癌中CD44v6 表达及与微血管密度和生物学行为的关系 |
| Expression of CD44v6 and its Relationship with Microvessel Densityand Biological Behaviour in Gastric Carcinoma |
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| DOI： |
| 中文关键词: 胃癌 CD44v6；微血管密度；浸润和转移 |
| 英文关键词: Gastric carcinoma CD44v6 MVD Invasion and metastasis |
| 基金项目:辽宁省科技攻关项目（2010225015） |
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| 中文摘要: |
| 目的：探讨CD44v6 在胃癌中的表达及其与微血管密度(microvessel density ,MVD) 和生物学行为的关系。方法：采用免疫组
化法检测80 例胃癌组织CD44v6、CD34 的表达,以CD34 标记肿瘤微血管,并在显微镜下计数微血管密度(MVD) 。结果：CD44v6
在胃癌组织中的表达与肿瘤浸润深度、临床分期、淋巴结转移相关(P<0.05) , CD44v6 强阳性表达组中MVD 明显高于CD44v6 阴
性表达组(P<0.05)。结论：CD44v6 的表达和MVD 计数是反映胃癌生物学特性的良好的指标，对判断胃癌的浸润转移具有一定的
临床意义。 |
| 英文摘要: |
| Objective: To discuss CD44v6 expression in gastric carcinoma and its relationship with microvessel density (MVD)
and biological behaviour. Methods: Using immunohistochemistry method to detect CD44v6 and CD34 in gastric carcinoma (n= 80).
Count microvessel density(MVD). Results: The expression of CD44v6 had correlation with the depth of infiltration, the TNM staging and
lymph node metastasis (P<0.05), The quantity of MVD in the group with CD44v6 strong positive was greater than that in the group with
CD44v6 negative (P<0.05). Conclusions: CD44v6 and MVD are valuable indicators for the biological characteristics of primary gastric
carcinoma and helpful in distinguishing malignant from benign tumors. |
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