| 贾瑞华王小木李晓伟王莹景芸芸崔晓丽江文△.常用抗癫痫药对癫痫患者血同型半胱氨酸的影响[J].现代生物医学进展英文版,2012,12(9):1665-1667. |
| 常用抗癫痫药对癫痫患者血同型半胱氨酸的影响 |
| Hyperhomocysteinemia in Epileptic Patients on Commonly UsedAntiepileptic Drugs |
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| DOI： |
| 中文关键词: 癫痫 叶酸 同型半胱氨酸 抗癫痫药物 |
| 英文关键词: Epilepsy Folate Homocysteine Antiepileptic drugs |
| 基金项目:国家自然科学基金资助项目（30870840; 81071051） |
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| 中文摘要: |
| 目的：观察常用抗癫痫药对癫痫患者血同型半胱氨酸、叶酸、维生素B12 浓度的影响。方法：比较45 例服用单药治疗的癫痫
患者（服用卡马西平11 例，服用拉莫三嗪12 例，服用奥卡西平9 例，服用丙戊酸13 例）血同型半胱氨酸、叶酸、维生素B12 浓度
的差异。结果：癫痫患者血同型半胱氨酸均高于正常，而叶酸和维生素B12 均在正常范围内；服用拉莫三嗪的患者其血中同型半
胱氨酸低于服用丙戊酸、卡马西平和奥卡西平的患者；服用卡马西平的患者血中叶酸高于服用拉莫三嗪、丙戊酸的患者（P<0.05）；
维生素B12 在各用药组间无统计学差异。结论：长期服用抗癫痫药物可引起血中同型半胱氨酸的升高，而高同型半胱氨酸血症可
增加心脑血管疾病的危险，故癫痫患者应常规给予补充叶酸、维生素B12，以使血同型半胱氨酸水平恢复正常。 |
| 英文摘要: |
| Objective: The aim of the present study was to observe the effect of commonly used antiepileptic drugs on plasma
concentrations of total (t) homocysteine (Hcy) in epileptic patients. Methods: Patients on antiepileptic drugs monotherapy, with no other
known cause of hyper-tHcy were enrolled. There are four groups tested. These groups were divided by drugs that patients used. Results:
Plasma tHcy levels of all epileptic patients were significantly higher compared to physiological levels (P<0.001). Normal folate and
vitmineB12 concentrations were observed in all subjects. Patients treated with lamotrigine exhibited mean plasma tHcy levels lower
plasma tHcy levels of patients treated with carbamazepine, oxcarbazepine and valproic acid (P<0.05). Folate levels in patients taking
carbamazepine were lower than those of patients treated with lamotrigine and valproic (P<0.05). Conclusions: Long-term antiepileptic
drug therapy contributes to hyperhomocysteinemic. Because hyper-tHcy is a significantly higher risk of cerebrovascular disease, patients
should be administered a supplement of folate and vitmineB12 to normalize plasma tHcy. |
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